Trimedat for pancreatitis - rules of administration and analogues

Qualitative characteristics of drug No. 1: “Trimedat” in the treatment of pancreatitis

The pharmaceutical industry, domestic and foreign, is constantly replenishing its market with innovative products. This includes antibiotics, exo/endoprotectors, glucocorticoid hormonal agents to treat pancreatitis. The leading place among them is occupied by Trimedat. He has deservedly proven himself:

"Trimedat", thanks to these targeted, dominant properties, effectively influences the rhythm of processes:

fermentation of food secretions coming from the stomach;
further processing of enzymes, breakdown of glucose, production of insulin;
in the joint ducts (gallbladder, duodenum, liver) through mutual circulation of organic, chemical microelements;
when destructive changes occur in the form of: spasm, neuroreceptor contractions caused by pancreatitis pathogenesis, it anesthetizes, relieves painful impulses, pain syndrome.

In addition to the listed abilities, the drug acts stably, thereby providing a long-term therapeutic effect. Effectiveness appears within 30 minutes after taking the prescribed dose. Stays in the body for 20-24 hours, has the property of sorption (absorption of harmful microflora).

Features of the use of Trimedat tablets for inflammation of the pancreas

When the pancreas becomes inflamed, pain often occurs. To relieve spasms and relax the walls of the organ, use an antispasmodic drug - Duspatalin. The drug has an effect on the smooth muscles of the gastrointestinal tract.

The drug is produced in the Netherlands, produced by Abbott Healthcare Products BV in tablets and capsules. The main active substance of the drug is mebeverine hydrochloride, which stops the flow of sodium and calcium ions into the cell, stopping muscle contractions.

About the medicine

The active ingredient of this drug is mebeverine. It modifies the functioning of ion channels in smooth muscle and prevents contraction of muscle fibers. It acts primarily on the organs of the digestive system, but does not reduce intestinal motility.

Duspatalin relieves only pathologically increased motility, without reducing normal one, and does not cause one of the common complications when using antispasmodic therapy - intestinal atony.

The main base substance of the drug is mebeverine. It is indeed included in many other drugs in the category of myotropic antispasmodics. But it happens that a person experiencing pain associated with pancreatitis acquires a “saving” medicine on his own. Only the difference in cost is taken into account, but not in the mechanism of action on the body.

What is better to take - tablets or capsules?

How to take Duspatalin for pancreatitis and what form of release to choose? These are questions related to the topic of “self-medication,” since inflammation of the pancreas (pancreas) is a serious pathology, and prescribing medications is the prerogative of a doctor.

However, this product is sold without a prescription, and its packaging includes instructions that clearly describe which forms (tablets, capsules) are most effective if pancreatitis is diagnosed. The drug has several dosage forms that are convenient for use - long capsules and coated tablets.

Tablet Duspatalin is recommended to be taken as follows:

shortly before meals, 20-30 minutes;
The tablet is taken whole and should not be chewed;
the medicine needs to be “helped” to be absorbed, and for this you need to wash it down with purified water (200-300ml);
as a preventive action against inflammation, the drug should be taken before each meal;
The medicine is also withdrawn gradually, the dosage is reduced every week - half a tablet, then a quarter, the specific regimen is prescribed by the doctor.

Duspatalin in capsule form is most effective for chronic forms of inflammation:

similar to Duspatalin tablets (this is especially important for chronic pancreatitis), taken only before meals (20-30 minutes before eating);
the capsule is swallowed whole, in order for this to happen easily, it is washed down generously (300-400 ml);
daily standard dosage - three times a day;
the course of therapy can be shortened, capsules have prolongation properties, that is, they are more effective and last longer;
the drug is discontinued according to the scheme, very correctly and gradually, the number of capsules taken is reduced to 1 per day.

Use in childhood

Duspatalin is prescribed to children over the age of 12 years. The permissible dosage involves taking 1 capsule of the drug 1 time per day, on an empty stomach in the morning.

The duration of treatment with Duspatalin for children depends on the dynamics of the drug effect. The medication is withdrawn gradually according to the scheme used for adults.

This is especially dangerous for people with chronic diseases of the cardiovascular, urinary or nervous systems. When taking antispasmodics, side effects of the drugs’ lack of selective action often occur:

arterial hypotension;
slowing heart rate;
inadequate supply of internal organs and tissues with oxygen.

Duspatalin exhibits a therapeutic effect directly in the intestines and does not affect the functioning of other human vital systems.

The risk of developing side effects from the urinary or cardiovascular system is minimized.

Unlike other antispasmodics, Duspatalin can be used for quite a long time, which is very important in the treatment of chronic gastrointestinal diseases.

The principle of action of the drug and its properties

The inflammatory process in the tissues of the pancreas is always accompanied by characteristic signs, the list of which includes spasm and intoxication. Accordingly, the first step in the treatment of pancreatitis is to prescribe a medication that relieves these discomforts.

Duspatalin has all the properties to solve the problem of pain relief and relief of spastic contractions.

The drug is included in the list of myotropic antispasmodics; it works specifically, relaxing only the contractile tissue of the gastrointestinal tract, without interfering with the general functions of the intestine and peristalsis in general.

The drug has specific pharmacological properties:

predominantly relaxes the musculus (muscle tissue) of the lower intestinal segment;
relieves pain and spasms quite quickly - after 15-20 minutes;
does not affect neurotransmission - impulse transmission along a nerve fiber:
acting directly on the tissue of the large intestine, does not disrupt the function of contraction and excretion:
the medicine does not affect the metabolism in the body;
the drug has a minimum of negative side effects on the body.

Why is Duspatalin so popular?

Duspatalin for pancreatitis has positive reviews not only from gastroenterologists, but also from many patients.

The medicine has proven itself to have a therapeutic effect faster than other drugs with similar effects and to relieve uncomfortable symptoms for a long time. This myotropic agent works well in combination with other medications, which gives the therapist ample opportunities for complex treatment of inflammation of the gastrointestinal tract.

A drug that is easy to take, has minimal risks and effects on the body, is effective and has analgesic properties - this is Duspatalin.

When treating pancreatitis, drug reviews are collected carefully and processed statistically correctly. In analytical reports, Duspatalin rightfully leads the list of drugs that help not only with diseases associated with the pancreas, but also in many other cases of gastrointestinal dysfunction.

Compound

The active component is mebeverine hydrochloride. One extended-release capsule contains 200 mg. Has a pronounced antispasmodic effect. At the same time, it does not disrupt intestinal motility or irritate the mucous membrane.

The Duspatalin capsule is coated with a special substance that is broken down only in the intestines, bypassing the acidic environment of the stomach. Mebeverine hydrochloride enters the systemic circulation and concentrates in pathological places. It is broken down by the liver and excreted by the kidneys.

Leaves the body completely within 24 hours. Not found unchanged in urine.

Qualitative characteristics of drug No. 1: “Trimedat” in the treatment of pancreatitis

"Trimedat", thanks to these targeted, dominant properties, effectively influences the rhythm of processes:

fermentation of food secretions coming from the stomach;
further processing of enzymes, breakdown of glucose, production of insulin;
in the joint ducts (gallbladder, duodenum, liver) through mutual circulation of organic, chemical microelements;
when destructive changes occur in the form of: spasm, neuroreceptor contractions caused by pancreatitis pathogenesis, it anesthetizes, relieves painful impulses, pain syndrome.

Duspatalin does not have a cumulative effect in the body and is excreted along with urine within 24 hours.

If a positive result is achieved from treatment with the drug Duspatalin, the amount of the drug should be reduced.

As a prophylactic against repeated attacks of pancreatitis, Duspatalin can be taken for a long time, up to 3 months or more. The course of treatment is prescribed and adjusted by the attending gastroenterologist.

Taking Duspatalin analogues for pancreatitis

In the treatment of pancreatitis, doctors very often prescribe analogues of the drug Duspatalin - this is Trimedat. Despite the fact that these drugs belong to the same group of medicinal myotropic antispasmodics, their effect on the body is slightly different due to their chemical composition.

Trimedat . The drug contains the antispasmodic trimebutine, milk carbohydrate, mealy corn carbohydrate, stearic acid with magnesium, silicon dioxide, silicate powder.

Duspatalin . The composition of the drug includes the antispasmodic mebeverine, stearic acid with magnesium, carboxylic acid polymer, silicate powder, methyloxypropylcellulose, glycerol triacetate.

As you can see, the drugs have different chemical compositions, so before answering the question of which is better for pancreatitis: Trimedat or Duspatalin, you should know what effect drugs have on pancreatic pathology.

The action of Duspatalin is primarily directed:

relief of pain;
prevention of repeated crises;
used in combination therapy.

Treatment of pancreatitis with an analogue of Duspatalin - the drug Trimedat should be carried out in the following situations:

Trimedat is more effective in cases of deterioration of muscle tone;
more significant in severe lesions of the pancreas;
does not require additional therapy, being a self-sufficient medicine.

When treating such a serious pathology as acute pancreatitis or a long-term pathology, you should definitely listen to the recommendations of a gastroenterologist - he knows which drug is better to prescribe: Trimedat or Duspatalin.

Acute pancreatitis

It is characterized by vivid symptoms and pain of varying intensity. The cause is inflammation of the pancreatic mucosa, indigestion, and muscle contraction.

Sometimes the spasm is so strong that it interferes with breathing, provokes dizziness, loss of consciousness, and increased blood pressure.

To prevent serious consequences, it is recommended to take the drug at the first alarming symptoms - bloating, pain in the abdomen, under the right rib, chest.

It becomes easier within 15 minutes, the effect lasts about 8 hours. It is necessary to begin qualified treatment aimed at eliminating inflammation. If the influence of negative factors is not eliminated, the condition will not begin to improve soon.

Some scientific studies say that Duspatalin cannot be used for acute pancreatitis, others say that it can. The instructions for use of the drug contain no contraindications to the use of the drug for acute pancreatitis.

On the contrary, acute manifestations of pancreatitis are accompanied by a large number of symptoms and manifestations that require the use of Duspatalin:

spasmodic pain;
pain in the intestines;
disruption of the flow of pancreatic juice in the sphincter of Oddi;
dyspepsia in the form of loose stools or constipation, accompanied by pain;

All of the above symptoms occur due to irritation of the processes of nerve fibers, which transmit nerve impulses and in turn provoke a narrowing of the Wirsung duct of the pancreas.

This process leads to severe pain and improper functioning of the gastrointestinal tract. In the future, if you ignore the process, what happens can provoke stone formation and lead to surgical intervention.

Pain in the intestines appears in acute pancreatitis due to insufficient supply of lipase, amylase, protease and, as a result, undigested food is an irritating, painful factor for the intestines.

With this manifestation, there may be such unpleasant and sometimes painful phenomena as constipation, diarrhea, heaviness in the abdomen.

An acute inflammatory process can affect nearby areas of the body and radiate pain to the lumbar spine, to the left hypochondrium (simulating heart pain). The pain of acute pancreatitis can be unbearable.

The first thing that needs to be done in this situation is to prescribe a strict diet, and also in case of exacerbation of pancreatitis, Duspatalin should be prescribed in complex therapy and in small doses (due to the small amount of food taken) so as not to overload the damaged organ.

It is necessary to take Duspatalin in tablets, they have a faster effect. You should take tablets (they have a lower dosage) 3 times a day, before eating diet food. The course of treatment determines the patient’s condition and the course of the disease.

Taking Duspatalin will help restore tone in the organ and normal functioning of the Wirsung duct, through which the organ will supply the enzymes necessary for processing food. The load on the intestines will be reduced.

The antispasmodic property of Duspatalin will cope with pain symptoms and tone the digestive system as a whole. Duspatalin is also one of the first drugs that relieves pain and is prescribed by a gastroenterologist to prevent the development of a shock state from pain.

Source: https://mgkb01.ru/osobennosti-primeneniya-tabletok-trimedat-pri-vospalenii-podzheludochnoy-zhelezy/

Effect on the pancreas

The use of Trimedat for pancreatitis is dictated by its gentle effect on the functioning of the pancreas and the ability to selectively influence the motor function of the gastrointestinal tract, relaxing spasmodic muscles or toning them during hypotension. Trimedat is a myotropic antispasmodic, the main active ingredient of which is trimebutine.

Whether it is possible to take Trimedat for pancreatitis in each individual case is decided only by a doctor, since this disease is not an indication for its use. Generally speaking, the drug has a positive effect on the condition of the pancreas. It helps to improve the passage of food through all organs of the digestive tract, which helps reduce the load on the weakened pancreas.

During the inflammatory process, enzymes that are naturally produced by the pancreas cannot enter the duodenum and are activated directly in the gland, beginning to slowly digest and destroy cells. This leads to the self-destruction of the organ. By relieving spasms from smooth muscles, the drug helps enzymes “cross” through the ducts of the gland into the intestines for further absorption of food.

Trimedat will also help when the patient has symptoms such as:

Intestinal obstruction;
Irritable bowel syndrome;
Gastroesophageal reflux disease.

When preparing the patient for x-ray or endoscopic examination of the gastrointestinal tract, this drug is also prescribed.

The use of Trimedat helps alleviate the condition of a patient who has undergone surgery on the digestive organs, in particular the stomach and pancreas.

Unlike many other drugs, this remedy can be used even for the treatment of young children if, due to underdeveloped motility of the digestive system, they often experience intestinal disorders.

Trimedat for chronic pancreatitis

Therapy for chronic pancreatitis consists of taking 300 milligrams of Trimedat daily - 100 milligrams at a time. The course of treatment is long - at least two or three months. Any remedy used for chronic pancreatitis does not work immediately. It will take at least two weeks before the therapy produces any noticeable results. That is why many impatient patients of gastroenterologists often abandon the treatment they have started or demand an immediate change in the drug. Unfortunately, the new remedy will not solve the problem. All that remains is to arm yourself with patience - as soon as the patient feels a positive change in well-being, further improvement in both the condition of the pancreas and the body as a whole will not take long.

Release form

In pharmacies you can find the following packages of tablets with Trimedat:

100 mg - 10-20 pieces (1-2 blisters) in a cardboard box;
200 mg - 10-20 pieces (1-2 blisters) in a cardboard box.

To prepare a suspension or perform intramuscular or intravenous injections, you can purchase the drug tribudate:

125 ml bottles (24 mg/5 ml) with powder for preparing a suspension;
Solution for injection 5 ml 50 mg - 3 ampoules in a cardboard box.

100-milligram tablets have a flat-cylindrical shape with characteristic, cross-shaped, intersecting indentations (they are convenient for breaking the tablet into four parts, which may be necessary if the patient is prescribed a lower dose of medication) on one side and the letters T and M (Trimedat) and six triangles ( three on top and bottom) on the other.

The 200-milligram tablets come in a slightly different form. They are round, biconvex, with two drop-shaped indentations on one side and an approximate line dividing each tablet into two equal parts on the other. Both forms of the drug are sold in blisters, each of which contains ten tablets hermetically sealed. Blisters are packaged in cardboard boxes, 1, 2 or 3 in each. Thanks to this, you can purchase exactly as much of the drug as prescribed, and at the end of the course of treatment you do not have to worry about what to do with almost the entire package.

Compound

The active ingredient of Trimedat is trimebutine. Its function is to regulate gastrointestinal motility. It is able to quickly relieve spasms of the intestinal walls and relax the smooth muscles of the digestive tract during a hyperkinetic state, as well as stimulate intestinal function during hypotension. The excipients included in the drug include:

Lactose;
Magnesium stearate;
Silica;
Talc;
Starch.

Contraindications and restrictions

Like other medications, this drug has contraindications. Trimedat is not recommended for use in the following cases:

intolerance to the components of the product;
pregnancy in the first trimester;
breastfeeding period;
individual contraindications.

The drug contains lactose, so it is not suitable for people with lactase deficiency. You also need to pay attention to other excipients, as they can cause allergies.

Trimedat can provoke an allergic reaction or cause an exacerbation of existing allergic diseases

Sensitivity to this medicine may manifest itself in the form of redness of the skin and rashes on the body, itching. Patients with chronic urticaria are especially prone to this reaction.

Trimedat should be used with extreme caution during exacerbation of pancreatitis.

In case of severe attacks, it is better to stop taking the medicine for a while. In any case, treatment should be supervised by a qualified physician.

As for the pregnancy period, in some cases it is allowed to use Trimedat in short courses. It does not have a toxic effect on the fetus, but is able to penetrate the placental barrier, and due to the lack of information on the effect on the development of the child, it is better not to use the drug unless absolutely necessary.

For the treatment of children, it is allowed to use products with trimebutine, but before reaching the age of three, tablets are prohibited; other forms of medication must be used. If there is no effect or suspicious symptoms appear, use of the drug is discontinued.

The dosage of Trimedat for children is two times lower than for adults

Pharmacokinetics of the drug

Trimedat is often used to relieve symptoms of gastrointestinal diseases. The drug detects its highest concentration 0.5-1.5 hours after taking the drug. During this time, it is absorbed in the intestines and penetrates the blood. Most of the drug is excreted in the urine in the first day. However, it does not have a cumulative ability and does not exhibit toxic effects on the kidneys, so the product can be used for a long time.

Trimebutine is able to regulate gastrointestinal motility, acting in isolation on the enkephalinergic system. In case of intestinal hypotension, it stimulates its work, and in hyperkinetic conditions, it effectively relieves spasms of the intestinal walls and relaxes the smooth muscles of the gastrointestinal tract.

With insufficient secretory activity of the pancreas, there are often situations when the absorption of food slows down and it stagnates in the stomach. Such phenomena reduce the motor activity of the intestine and lead to the growth of pathogenic flora in it. In such cases, gastroenterologists usually recommend taking Trimedat.

It has the necessary effect, significantly improving the patient’s condition:

relieves pain and discomfort in the abdomen, eliminates cramps and bloating;
improves intestinal motility in the presence of problems with stool;
eliminates motility disorders of the sphincter of Oddi and the biliary tract, eliminates congestion in the gastrointestinal tract;
improves the transportation of food masses;
alleviates the patient's condition with postoperative intestinal obstruction.

Due to this effect of the drug on the gastrointestinal tract, it can help with the following symptoms:

unstable stool;
feeling of heaviness in the stomach;
nausea or vomiting;
discomfort under the left rib or upper abdomen;
IBS.

Trimedat is widely used for both therapeutic and diagnostic purposes. It is used to prepare the patient for diagnostic measures to examine the abdominal cavity (endoscopy, x-ray).

The active substance of Trimedat, trimebutine maleate, is part of the group of myotropic antispasmodics. It affects the contractility and tone of the smooth muscle structures of all digestive organs from the esophagus to the rectum. It has been proven that the site of the pharmacological mechanism of action is numerous receptor sites in smooth muscles. They exchange mediators responsible for ensuring the movement of food.

Remembering the anatomy, we note that the pancreas is a parenchymal (not hollow) organ, like the stomach and intestines. It does not have a pronounced muscle wall, but is covered with a capsule. How does Trimedat work in this case?

One of the main pathogenetic causes of pancreatitis is considered to be obstruction of the pancreatic ducts (stones, tumor, cystic formations). Stagnation in the neighboring duodenum, transverse colon and stomach compresses the gland mechanically.

The secretion excretion system consists of small tubules, larger ones merging with each other. At the border with the duodenum, the overall release of pancreatic juice and bile into the intestine depends on the state of the muscular sphincter (sphincter of Oddi).

It is the walls of the ducts that include smooth muscles and form waves of peristalsis. Trimebutine acts on them, restoring patency and the release of enzymes into the intestines.

The main cause of acute pancreatitis is the inability to promote enzymes, stretching and stagnation in the lobules of the gland, release of enzymes into the tissue and self-destruction of the organ. In a chronic process, inflammation forms areas of connective tissue (scars) that are unable to produce enzymes. Pancreatic insufficiency gradually develops. The effect of trimebutine on the movement of digestive juices into the intestines helps restore impaired digestion, absorption of nutrients, and their entry into the bloodstream.

Indications for use

Typically, the reason for prescribing drugs with trimebutine are gastrointestinal pathologies associated with functional disorders.

The drug is used for many diseases of the digestive system as a symptomatic remedy and to improve the process of food digestion.

Trimedat is recommended in the following cases:

IBS;
unstable stool;
reflux esophagitis;
nausea and vomiting;
discomfort and cramps;
congestion in the gastrointestinal tract;
decreased intestinal motility;
intestinal obstruction after surgery;
flatulence and increased gas formation;
stagnation of pancreatic juice and bile.

Due to the fact that the drug eliminates congestion and a feeling of fullness in the stomach, relieves nausea and improves intestinal motor functions, it is often used for inflammation of the pancreas. In addition, Trimedat is sometimes included in preparatory measures before diagnostic procedures.

Indications and contraindications for taking Trimedat for illness

In case of pathology of the pancreas, doctors prescribe Trimedat to eliminate the symptoms of impaired digestion of food:

shingles pain in the upper abdomen;
spastic colic around the navel;
bloating, increased gas formation;
diarrhea and constipation;
belching and vomiting;
reflux of food into the esophagus;
heartburn;
irritable bowel syndrome.

Trimedat is rarely included in the patient’s preparation for diagnostic procedures to eliminate constipation and bloating.

The drug is contraindicated in the following:

increased sensitivity to components;
during pregnancy and lactation;
lactose and galactose fermentopathy.

Acute pancreatitis

Acute pancreatitis is accompanied by intense pain and vomiting. The pancreas is isolated as much as possible from any irritating factors (hunger, administration of only parenteral drugs, tube gastric lavage). During this period, the use of Trimedat is strictly contraindicated. Under no circumstances should you take the medicine as a first aid remedy without consulting a doctor.

The doctor will tell you when you can start adding a myolytic to your diet and complex therapy. Judging by his condition and blood tests, the disease should go into stable remission. At the same time, the diet is expanded, and drugs with pancreatin are added to therapy. A dosage of 600 mg may be required initially, then progressed to 300 mg per day.

Dosage and rules of administration

The drug Trimedat has different release forms (100 and 200 mg). To ensure a complex effect for pancreatitis, it is necessary to take the drug in combination with other agents that improve the functioning of the gland. The regimen and duration of therapy is determined by a gastroenterologist.

In the treatment of children, the following maximum daily dosages are accepted:

child from 3 to 5 years old – 75 mg in one dose;
children from 6 to 12 years old – 150 mg;
Adolescents over 12 years of age and adult patients can take up to 300–600 mg.

Do not exceed the indicated dosage unless there are any instructions from the doctor. Use with caution in IBS. There is no information about an overdose of the drug, but in this case it is better to contact a medical facility.

Trimedat should be taken three times a day before meals with water. It is not advisable to use milk, tea or juice for these purposes. In some cases, an additional course of therapy may be necessary to maintain adequate gastrointestinal function. The drug is usually prescribed at half the dosage for 1–3 months, depending on the diagnosis and instructions of the specialist.

Trimedat is a tablet drug intended for oral administration. The tablet should be taken whole, without chewing, with half a glass of boiled water at room temperature.

It is most advisable to take Trimedat 30-40 minutes before meals, but if taking the drug on an empty stomach causes discomfort, you can take the tablet an hour after meals. The effect of Trimedat begins 30 minutes after consumption on an empty stomach and a little later on a full stomach.

The maximum concentration of the drug in the blood is reached an hour or an hour and a half after administration.

Trimedat is taken one tablet (100 or 200 milligrams) three times a day, very preferably at strictly designated hours (for example, at 7:00, 13:00 and 19:00). Treatment with this drug takes a lot of time: to prevent exacerbation of pancreatitis or relapse of irritable bowel syndrome, Trimedat is taken for three months.

Adverse events and contraindications

The drug is completely contraindicated in the following conditions:

in the first trimester of pregnancy;
in case of individual intolerance to the components of the drug;
during lactation (cancellation required);
in early childhood (up to 3 years).

If the recommendations specified in the instructions for the drug and the doctor’s prescriptions are fully followed, the drug rarely exhibits undesirable effects. Even if side effects do occur, they are usually mild and resolve spontaneously.

Undesirable effects when using Trimedat include allergic skin manifestations that occur due to increased sensitivity to the components of the drug.

Very rarely, the drug can cause the following pathological manifestations:

transient hearing loss;
skin rashes;
feelings of causeless anxiety;
disruptions of the menstrual cycle;
disorders of the gastrointestinal tract due to lactose intolerance;
heart rhythm disturbance.

These manifestations go away on their own after stopping the use of the medicine. The severity of allergic manifestations can be reduced by successively reducing the dose of the drug. This makes it possible to continue further treatment with the drug Trimedat. In case of significant deterioration of the patient's condition, the use of the drug is completely excluded.

Side effect

The almost complete absence of side effects gives particular value to a drug such as Trimedat. According to the instructions, occasionally taking this medication can cause an allergic reaction, manifested in the form of skin rashes. True, other sources indicate that in some cases the body may respond to taking the drug with a short-term decrease in hearing, a feeling of causeless anxiety, tachycardia, nausea and diarrhea (if the patient is lactose intolerant). You should not be afraid of this, however, at the first signs of an unusual reaction of the body, you should immediately consult your doctor. In the vast majority of cases, neither special treatment nor drug withdrawal is required. It is enough to reduce the dose and the condition will soon return to normal.

Contraindications

Trimedat is one of the few drugs that has virtually no contraindications. It is not used only for the treatment of children under three years of age and adult patients suffering from intolerance to its individual components. Practice shows that there are very few patients intolerant to this drug: as a rule, it is very well tolerated by the body.

It is not advisable to take the drug in the first three months of pregnancy, as well as during breastfeeding.

Since no one has conducted research on the effect of the drug on the body of an infant, using it during this period would be an unjustified risk.

In case of emergency, if the mother’s health condition does not allow further delay of drug treatment, the baby is temporarily transferred to an artificial formula.

Trimedat cannot be combined with alcoholic beverages. During treatment, patients should completely abstain from alcohol.

Reviews from doctors

Arthur, Nalchik

“With peace of mind I prescribe Trimedat to my patients. This is one of those drugs that almost instantly alleviates the patient’s condition with irritable bowel syndrome and reduces the symptoms of pathologies such as biliary dyskinesia. In addition, Trimedat has no – or almost no – side effects, and this property is not inherent in all effective drugs. In my practice, only one patient developed a slight tachycardia after taking a dose of the drug. By reducing the dose by a third, we were able to ensure that heart function quickly returned to normal.”

Violetta, Moscow

“A drug like Trimedat copes well with the symptoms of pancreatitis: reflux and constipation. The good news is that it can be given to children from three years old. The only thing that upsets us is the cost, but there are analogues on sale at a much more reasonable price that almost anyone can purchase.”

Analogues and compatibility with drugs

Trimedat combines well with almost any drug without showing any specific interaction. This feature of the drug makes it possible to use it in the complex therapy of many diseases accompanied by dysfunction of the digestive system.

For diseases of the pancreas, as well as many other diseases of the gastrointestinal tract with similar symptoms, it is allowed to use analogs of Trimedat. They also contain trimebutine, but its concentration may be higher or lower, and it may also contain additional components.

The following drugs are analogues of Trimedat:

Debridat;
Neobutin;
Trimedat Valens;
Trimebutine maleate;
Trimebutine;
Tribudat.

Drugs with similar effects (matches according to level 4 ATC code) are Duspatalin, Meverin, Niaspam, Aprofen.

Trimedat is available in the form of tablets, solution for intramuscular administration and powder for suspensions. Debridet contains trimebutine in the form of a powder for diluting a suspension, which is convenient in pediatric therapy. Suspensions are allowed to be used to treat children from six months of age.

In severe cases, infusion therapy will help. The drug should be administered intravenously slowly (up to several minutes). During the treatment period, consuming alcoholic beverages is unacceptable; this will slow down the treatment and negatively affect the patient’s health.

In general, the drug Trimedat has proven itself well in the treatment of gastrointestinal pathologies and in the complex therapy of pancreatitis in particular. The pharmacological agent restores the motility of the gastrointestinal tract and accelerates the healing process. Trimedat effectively eliminates the symptoms of the disease, exhibits excellent compatibility with other pharmacological agents and practically does not cause undesirable effects.

Duspatalin and Trimedat differ in composition and content of the active ingredient. There is partial similarity only in the list of excipients: the drugs contain talc and magnesium stearate. The remaining components of the drugs are different.

Among the forms of both medications there are no solutions for intramuscular injections. Medicines are taken orally.

The action of the drug Trimedat is based on its effect on intestinal opiate receptors. Depending on the excitation or inhibition of one or another type of these nerve cells, the medicine can both fix the stool in case of diarrhea, and have a mild laxative and antispasmodic effect in case of constipation. Trimedat is especially effective for irritable bowel syndrome: the disease is characterized by alternation of both conditions, flatulence or bloating.

The active ingredient Trimedat (trimebutine) has a stimulating effect on the muscles of the intestines and digestive tract.

Price

The average cost of Trimedat is approximately 1,700 rubles. The price of the cheapest versions of the drug from little-known manufacturers is only 950 rubles. The most expensive packaging costs 2,500 rubles.

The cost of analogues of this medicine is as follows:

Trimebutin – 300 rubles,
Trimebutine maleate – 260 rubles,
Tribudat – 311 rubles,
Trimedat Valenta – 1400 rubles,
Neobutin – 330 rubles,
Debridet – 600 rubles,
Aprofen – 1700 rubles,
Duspatalin – 360 rubles,
Niaspam – 420 rubles,
Meverin – 550 rubles.

Which is better: Trimedat or Duspatalin?

The effect of each drug depends on the patient's condition. For those suffering from constipation of various origins, Trimedat and its analogues containing trimebutine are considered the drug of choice. It reduces intestinal transit time and promotes easier bowel movements by changing the consistency of stool. With increased peristalsis and associated symptoms (pain, diarrhea, etc.), Trimedat has a calming effect and relieves unpleasant symptoms.

Duspatalin acts differently and simply relaxes the muscles during intestinal spasms, biliary colic or chronic pancreatitis. For gastrointestinal diseases associated with excessive tension (spasms) of smooth muscles, and the resulting abdominal pain, the doctor will most likely prescribe Duspatalin.

The drugs are compatible. But a treatment regimen must be developed by a specialist who, together with Trimedat and Duspatalin, will prescribe probiotics, anti-inflammatory, laxatives and other types of medications to eliminate intestinal dysfunction or inflammation of the gallbladder and pancreas.

Analogs

If you suffer from pancreatitis or other diseases of the digestive system, in addition to Trimedat itself, you can take its analogues. They also contain trimebutine, however, the concentration of this substance in different drugs may vary. In addition, if you are allergic to one of the components of Trimedat, you can always choose a high-quality analogue that does not contain it.

Drugs similar to Trimedat are:

Trimebutin,
Trimebutine maleate,
Tribudat,
Trimedat Valens,
Neobutin,
Debridat.

Drugs similar in action to Trimedat include:

Aprofen,
Duspatalin,
Niaspam,
Meverin.

In conclusion, I would like to note that so far no cases of Trimedat overdose have been identified. This drug does not affect the ability to drive vehicles and motor skills, which means it can be used without interrupting the work process.

Reviews about the drug

The medicine receives positive reviews from patients in more than 90% of cases. This is explained by its high effectiveness in the occurrence of dyspeptic symptoms, as well as ease of administration. The tablets quickly eliminate spasms in the intestines, relieve colic, abdominal pain, relieve gas accumulation, “start” the stomach, and speed up the passage of food into the intestines.

Trimedat as an antispasmodic has a rapid effect even in severe pancreatitis. Many patients, when choosing which works better for pancreatitis, Duspatalin or Trimedat, note that the effectiveness of the second drug is higher. Although Duspatalin is considered one of the most effective drugs for spasms in the gastrointestinal tract.

Sources: gastrolekar.ru/pankreatit/trimedat.html https://pankreatit03.ru/trimedat-pri-pankreatite.html https://ogkt.ru/preparaty/trimedat-pri-pankreatite.html https://pankreatit.guru /lechenie/preparaty/spazmolitiki/trimedat https://pankreatita.net/blog/lekarstva/spazmolitiki/trimedat prozkt.ru/lekarstvennye-preparaty/trimedat-pri-pankreatite.html pankreotit-med.com/trimedat-pri-pankreatite- otzyvy-instrukciya/ https://pillsman.org/28098-trimedat-pri-pankreatite.html This material is exclusively subjective and is not a guide to action. Only a qualified specialist can determine an accurate diagnosis and prescribe treatment.

Last modified: 03/20/2020