DUSPATALIN OR NO SPA: which is better and what is the difference (differences in compositions, reviews from doctors)

NO-SPA reviews about the drug

Name:

Lina Feldt
Review:
thank you so much. During menstruation it is the only thing that helps

Name:

Nata
Review:
No-Shpa has long been the number one lifesaver for me! But recently in one pharmacy they began to recommend me another drug, which is many times more expensive, but the main motivation is that all of Europe has already abandoned No-Shpa, only Russia consumes it, and I I really now doubt how harmful No-Shpa is, maybe it’s worth not skimping - health is more expensive.

Name:

Trinapas Hapkin
Review:
thank you so much. During menstruation it is the only thing that helps

Name:

Mr.
Review:
thank you but shpe helps with severe headaches

Name:

Vikochka
Review:
No-spa has never helped me with anything. In my opinion, it is a completely useless drug.

Name:

olesia ilyasova
Review:
just for each drug individually, it suits some, but not others

Name:

Alexandra Kishkina
Review:
helps out in any situation.

Name:

Severe
Review:
Excellent product! You need to have it with you at all times if a person has problems with pain. Although for some reason it doesn’t save everyone.

Name:

Owl
Review:
I am generally allergic to no-shpu.

Name:

Ivan Shadrin
Review:
No-spa helps me with gastrointestinal spasms. Some people recommend drinking Unispaz, which contains codeine, which is a drug.

Name:

Zoya Gorinova
Review:
NO-spa helps me with spasms in the gastrointestinal tract.

Name:

Sheridan
Review:
It helps me with spasms in the gastrointestinal tract, but the expensive meteospasmil and duspatalin were almost ruined, the pressure began to rise, then drop, and so on several times, they took me away in an ambulance

You can buy natural remedies for the gastrointestinal tract here

Promo code for discount MAT6375

Name:

Irina
Review:
It never helps, I bought it once, tried to relieve pain during menstruation - zero results, got sick quickly - zero results, bloating - zero results.

Name:

Not a good girl
Review:
No-spa has never helped me with anything. In my opinion, it is a completely useless drug.

Name:

Magadan Aero
Review:
it helps me well with pain before critical days. Just like some kind of ambulance. But I drink when I can no longer bear it, because... I hate pills in general.

Name:

dobroy.ru
Review:
But - shpa. Contraindicated for prostate adenoma - and when injected it causes urinary retention - and when administered intravenously - a sharp drop in pressure

Name:

Athena la Belle
Review:
No-spa has never helped me with anything. In my opinion, it is a completely useless drug.

Name:

Lyudmila Baryshnikova
Review:
…….TO WHOM DATES. TO WHOM PORK CARTILAGE…..BUT WHEN IT HURTS. THEN YOU CAN EAT THE MOUSE. IT DID NOT HURT

DUSPATALIN reviews about the drug

Duspatalin - is it an antibiotic or not?

This drug belongs to the group of antispasmodic drugs with myotropic action. The analgesic effect of the drug is due to the presence of mebeverine hydrochloride, a chemical compound that does not have any of the effects of antibacterial agents, is not capable of stopping the growth of bacteria or killing microorganisms and cannot be an antibiotic.

Analogs

There are many drugs on the pharmaceutical market that are analogues of Duspatalin, since the main active substance of these drugs is mebeverine hydrochloride. The difference between these drugs is that Duspatalin is an original drug, that is, it was first developed and registered by the company that produces it.

In addition to Duspatalin analogues, there are many other drugs from the group of myotropic antispasmodics that have the same therapeutic effect. The most popular antispasmodic drugs are:

• No-spa - relieves spasms of neurogenic and muscle origin. The main active ingredient is drotaverine hydrochloride. International nonproprietary name (INN) – Drotaverine. Available in tablets.
• Trimedat is a drug characterized by an antispasmodic effect. The action of Trimedat is aimed at improving gastrointestinal motility. The active ingredient is trimebutine maleate. INN of the drug is Trimebutin. Trimedat is available in tablets.
• Bendazole is a myotropic antispasmodic, which also has vasodilating, tonic, adaptogenic, and immunostimulating effects. The main active ingredient and INN is Bendazole. It is an analogue of Dibazol. Release form: injection solution or tablets.
• Buscopan is an antispasmodic and anticholinergic blocker with local action. Active ingredient and INN – hyoscine butyl bromide. Available in the form of rectal suppositories (suppositories).
• Dibazol is a myotropic antispasmodic, the original Bendazol. Available in the form of injection solution and tablets.
• Papaverine is a myotropic antispasmodic and vasodilator. Reduces the tone of smooth muscles of internal organs and blood vessels. The active ingredient of the drug is papaverine hydrochloride, and the INN is Papaverine. Available in the form of rectal suppositories, injection solution or tablets.

Dicetel or Duspatalin - which is better?

Most doctors recommend using original medicines, since in the production of analogue medicines it is possible to use other excipients or change production technology, which, theoretically, can negatively affect the quality of the medicine. Dicetel is a drug from the group of myotropic antispasmodics, which is the original Pinaverium and contains pinaverium bromide as an active ingredient.

It cannot be said that one of these medications is better than the other, since they are both applicable for functional disorders of the gastrointestinal tract, biliary, intestinal colic and other diseases accompanied by spasm of smooth muscles. Only a doctor can make a choice in favor of one of these medications, taking into account the individual characteristics of the patient.

Analogues of Duspatalin: Sparex, Niaspam, trimedat and No-Shpa

Duspatalin is a representative of the group of myotropic antispasmodics, which normalizes the spastic and myotropic activity of the digestive organs. Duspatalin's analogue does not always consist of the same active ingredient. Drugs may belong to the same pharmacological group, but differ in a number of properties (pharmacokinetics, bioavailability, etc.).

Before replacing the drug and selecting suitable generics, you must carefully study the composition, dosages, dosage forms and consult with your doctor. The drug can be purchased at the pharmacy in the form of capsules or tablets for oral administration. The active substance is mebeverine hydrochloride, due to which the following is observed:

1. Elimination of pain impulses provoked by spasms.
2. Normalization of blood circulation and organ nutrition.
3. Relaxation of the smooth muscles of the digestive organs.

Duspatalin is used for irritable bowel syndrome (IBS), pancreatitis, cholecystitis.

Advantages of Duspatalin over cheaper analogues

Among the advantages of the analogue medicine are:

1. Long-term pharmacological effects.
2. No toxicity.
3. High tolerance.
4. Selectivity (selective influence).

The manufacturer of Duspatalin is the pharmaceutical company Solvay Pharmaceuticals, located in the Netherlands. The drug can be purchased in the form of extended-release capsules, a more convenient dosage form for people who cannot use tablets several times a day.

Comparison of Duspatalin with other drugs

Before selecting a suitable replacement drug, you should carefully study the instructions for use of the potential analogue, its pharmacological properties, and comparative characteristics. Selection of a replacement may be required if:

1. I am not satisfied with the price of the original drug.
2. Reactions of intolerance to active or auxiliary substances.
3. The patient has contraindications.
4. During therapy, the development of undesirable side reactions is observed.

If the patient intends to buy an exact structural analogue with an active substance similar to Duspatalin, then it is worth discussing with the doctor the use of Niaspam, Sparex, Mebeverine, as well as Odeston, Motilium, Ganaton.

Which is better: Trimedat or Duspatalin

Trimedat is a substitute drug that is often prescribed by gastroenterologists to patients with dysfunction of the gastrointestinal tract. Available in the form of tablets for oral administration. The drug is not an exact structural analogue of Duspatalin; the manufacturer uses trimebutine as the active component:

1. The active substance Trimedat interacts with a number of receptors that inhibit intestinal motility. This helps cope with common symptoms of irritable bowel syndrome such as diarrhea and constipation.
2. Trimedat helps cope better with constipation, Duspatalin helps with the development of spasms.
3. Randomized clinical trials have found a reduction in pain in more than 50% of patients after a month of regular use of Duspatalin. Taking both Duspatalin and Trimedat can significantly improve the quality of life and cope with the symptoms of gastrointestinal diseases, including irritable bowel syndrome.

Trimedat stimulates the muscles of the gastrointestinal tract. Only a gastroenterologist can answer the question of which is better, taking into account the indications for use and the patient’s accompanying complaints.

Niaspam

Niaspam is an analogue of Duspatalin, a representative of the group of myotropic antispasmodics with the original composition. Available in the form of capsules for internal administration with prolonged action. Differs by manufacturer (India).

Raw materials are of lower quality, hence lower price. The drug is used in complex treatment regimens for various diseases of the gastrointestinal tract, accompanied by spasms.

The drug helps cope with pain caused by irritable bowel syndrome.

The active component of Niaspam is released from the capsule gradually, which allows for a more prolonged effect.

The drug is similar in composition, but the list of auxiliary components may differ slightly. The main difference is the manufacturer and therefore the quality of the raw materials used.

Both Niaspan and Duspatalin are well tolerated and have a pronounced therapeutic effect.

Sparex

Patients often have a question: Sparex or Duspatalin - which is better? Sparex is an exact structural synonym with a similar active component.

Presented in the form of capsules for internal use, which help cope with intestinal colic, spasms of the gastrointestinal tract, and indigestion.

This is a Russian-made drug that should be used twice a day (morning and evening), before the main meal. Taking the drug is contraindicated:

1. Patients under 12 years of age.
2. If you are intolerant to mebeverine.
3. For porphyria.
4. During pregnancy.
5. Therapy for nursing women requires special care.

Sparex is well tolerated, but in some cases dizziness, bowel movement disorders, headaches, and allergic manifestations have been reported.

Differences between No-shpa (Drotaverine) and Duspatalin

No-spa is a medicine for patients with spasms affecting the muscles of the gastrointestinal tract.

No-spa should not be used in case of renal and liver failure, low blood pressure, or female representatives during breastfeeding.

The drug can increase the process of sweating and increase heart rate. The main difference between the drugs is in the composition, as well as a number of characteristics.

Important! Duspatalin has a longer period of pharmacological action, but also a higher cost.

Mebeverine and Duspatalin: what to choose?

Mebeverine is the active ingredient in the original tablets and capsules; the drugs act in a similar way. Can be used as a more affordable replacement with prior agreement with a doctor, who will take into account the possible need to recalculate the dosage, frequency and duration of use.

Mebeverine is used in the treatment of adult patients who have complaints of spasms caused by various diseases of the gastrointestinal tract. The tablets will also help cope with colic and digestive disorders. The manufacturer recommends using the medicine before the main meal.

Is it possible to replace Meteospasmil?

Meteospasmil helps cope with digestive disorders, accompanied by increased gas formation, bloating, nausea, abdominal pain, and belching. The drug is often used in preparation for x-ray examination of the gastrointestinal tract. Duspatalin has a wider range of applications and selective effects.

The possibility of replacing Meteospasmil should be discussed with your doctor. Both medications should be used in strict accordance with the indications for use, taking into account age restrictions, contraindications, and possible side effects.

Dicetel

Dicetel is a medicine based on pinaverium bromide, which helps reduce the sensitivity of neurons and reduces pain impulses in the gastrointestinal tract. Dicetel helps cope with the following pathologies:

1. Intestinal spasms.
2. Disturbances in the functioning of the gastrointestinal tract and pancreas in acute form.
3. Dysfunction of the biliary system, gallbladder disease.

The drug can be purchased at the pharmacy in the form of tablets for oral administration, which are used up to 3 times a day. Dicetel should not be used by pregnant women, patients with intolerance to active or auxiliary substances, or when treating pediatric patients. Taking tablets may be accompanied by nausea, dyspepsia, and difficulty defecating.

Kolofort: differences from Duspatalin

Colofort is a representative of the group of antispasmodics, which is available in the form of tablets for oral administration. Helps cope with dysfunction of the gastrointestinal tract, including irritable bowel syndrome, as well as urolithiasis.

Unlike Duspatalin, Kolofort is a multicomponent medicine that provides nervous and humoral regulation of the functions of the gastrointestinal tract.

Medicines also differ in the method of administration: Duspatalin tablets or capsules are taken orally with water, while Colofort should be kept in the mouth until the medicine is completely dissolved.

Iberogast

Iberogast - drops for oral administration, which are used to eliminate heaviness in the stomach, colon dysfunction, belching, abdominal pain, diarrhea, constipation, flatulence. It has a multi-component herbal composition and is well tolerated.

The drops should be used for 30 days, after which you need to take a break. Iberogast can act as a herbal replacement for Duspatalin. The mechanism of action and composition of drugs differ significantly.

The drug may adversely affect patients with intolerance to plant substances.

Prices for foreign and Russian analogues of Duspatalin

The price for Duspatalin starts from 470 rubles. for 30 capsules of prolonged action and 730 rub. – for 50 tablets. Prices for the list of analogue drugs, including domestically produced ones, are formed as follows:

1. Trimedat – 470 rub.
2. Niaspam – 420 rub.
3. Sparex – 390 rub.
4. No-Shpa – 70 rub.
5. Drotaverine – 30 rub.
6. Meteospasmil – 490 rub.
7. Dicetel – 570 rub.
8. Kolofort – 400 rub.
9. Iberogast – 570 rub.

Price is not always an indicator of the best quality and effectiveness of a drug. Tolerability of the drug is individual for each patient and depends on a number of factors: age, degree of disease progression, and the presence of concomitant disorders.

Source: https://mfarma.ru/pankreatin/perechen-analogov-dyuspatalina-dostupnye-dzheneriki

But spa and duspatalin at the same time

What is the difference between these drugs, can they be taken at the same time - what is the compatibility. Is this the same thing or what is better? but spa and duspatalin

Author of the publication

anastasiya.value

Achievement received 06/09/2019

Similar:

Duspatalin and No-shpa belong to the same group of antispasmodics. Used for pain and spasms of the gastrointestinal tract. No-spa has little effect on pain syndrome. But Duspatalin helps well with all kinds of intestinal disease syndromes, biliary colic and pancreatitis. I had problems with my gallbladder. The doctor chose Duspatalin. And he reminded that this drug should under no circumstances be combined with No-shpa, drotaverine, or papaverine. Otherwise, an overdose of the drug may occur, which will lead to dire consequences. So in any case, you should choose one of these drugs. In this matter, a person should not choose a medicine on his own. It must be prescribed by a doctor. Self-medication is contraindicated.

These drugs are both antispasmodics of the same group, but Duspatalin is more aimed at reducing pain and unpleasant conditions in the gastrointestinal tract. And No-spa has a wider range of applications: for diseases associated with the biliary tract, urinary system, gastrointestinal tract, tension headaches, and pain during menstruation, in some cases during painful childbirth. Therefore, it is not worth calling both drugs the same thing, since they do not act exactly the same and are intended for different organs. The composition of the drugs is also different. Taking Duspatalin and No-Shpa in combination at the same time is quite acceptable and the effect of their combined use will be a stronger analgesic effect. For a specific disease, one of these drugs may be better - more suitable, so everything is individual. Both drugs themselves are not bad, they are mutually compatible and require consultation with a doctor regarding their use for a specific disease and existing contraindications, as well as compatibility with other drugs.

Duspatalin and No-Shpa belong to the group of myotropic antispasmodic drugs. These medications are used to relieve pain of various etiologies. Many patients would like to know which is better, No-Shpa or Duspatalin. Let's try to understand how these substances work.

The active ingredient of No-Shpa is drotaverine, which blocks the activity of the phosphodiesterase enzyme, thereby increasing the concentration of cyclic adenosine monophosphate, which causes relaxation of smooth muscles.

Mebeverine - the active substance of Duspatalin acts on the smooth muscles of the gastrointestinal tract (mostly on the large intestine), relieving spasm. The drug does not affect peristalsis and does not inhibit acetylcholine receptors.

Both agents have a relaxing effect on smooth muscles. Therefore, it is not possible to determine which drug is better in this parameter.

Duspatalin or no-spa: which is better and what is the difference (differences in composition, reviews from doctors)

Pain and spasm are the most common symptoms of diseases of the stomach and intestines. To correct the condition, antispasmodics are prescribed, for example, Duspatalin or No-shpa. The choice of drug depends on the characteristics of the disease and the patient.

How they affect the body

The main component of No-shpa is drotaverine. The active substance of Duspatalin is mebeverine. Both substances have an antispasmodic effect. Both medicines are direct-acting drugs.

pharmachologic effect

The drugs change the ionic balance in cells, triggering chemical reactions that reduce smooth muscle contractions. As a result, muscles relax, blood pressure decreases, and blood vessels dilate.

The spasms go away. Medicines do not affect normal intestinal motility. Medicines are completely eliminated from the body. The half-life is 10 hours. Within 72 hours, the drugs are completely eliminated through urine and feces.

No-shpa or Duspatalin: which is better?

Differences between No-shpa and Duspatalin:

1. Manufacturer. The first medicine is produced in Hungary, the second in the Netherlands.
2. Release form. The first product is produced in the form of tablets and ampoules for injections, the second - in the form of capsules and tablets.
3. Contraindications and side effects. No-shpa has a longer list, Duspatalin is safer.
4. Treatment during pregnancy and breastfeeding. During breastfeeding, only Duspatalin can be used; during pregnancy, both medications can be used.

Duspatalin is suitable for the treatment of pain due to colic, intestinal or stomach upset. The scope of application of No-shpa is wider. This remedy helps with any pain and cramps, for example, with headaches, menstrual pain, cystitis, and recovery after surgery.

Thus, for the treatment of pain and spasm in the gastrointestinal tract, it is better to choose Duspatalin. Its action lasts longer and is aimed exclusively at correcting intestinal function. If you suffer from pain in another area, then you should choose No-shpa. It affects all smooth muscle, while the other medicine only affects intestinal smooth muscle. No-shpa is also suitable for quick pain relief.

The choice of medication depends on the course of the disease and the individual characteristics of the client. Instructions for use are advisory in nature. What is best to use in a particular case is determined by a specialist.

Indications for use

Indications for use of No-shpa:

• intestinal spasms due to gastrointestinal diseases;
• spasm of the urinary and biliary tract;
• painful menstruation;
• ulcer, gastritis, colitis, enteritis, pancreatitis (auxiliary therapy);
• spasms in the genitourinary system;
• spasm due to cholecystolithiasis, cholangiolithiasis, cholecystitis, pericholecystitis, cholangitis, papillitis);
• cephalgia;
• painful labor pains.

Indications for use of Duspatalin:

• intestinal and biliary colic;
• spasm of smooth muscles of the gastrointestinal tract, including against the background of infections and organic lesions);
• irritable bowel syndrome;
• recovery after surgery to remove the gallbladder;
• intestinal pain on a psychosomatic basis;
• gastrointestinal dysfunction.

In pediatrics, the medicine is prescribed to relieve pain in functional gastrointestinal disorders. The drug is allowed to be taken by children over 12 years of age.

Directions for use and dosage

Features of taking Duspatalin:

1. The tablets are taken 15 minutes before meals. On average, one tablet is prescribed three times a day.
2. Capsules should be taken 25 minutes before meals, one capsule twice a day. Do not chew the capsule or spill its contents.
3. The general course of medication is prescribed by the doctor. Abrupt discontinuation of treatment is unacceptable; a slow reduction in dosage is indicated.

Features of taking No-shpa:

1. Adults are prescribed 1-2 tablets twice or thrice a day, no more than 240 mg of drotaverine per day.
2. Children over 12 years old are given two tablets 1-2 times a day, no more than 160 mg of drotaverine per day.
3. Children from 6 to 12 years old: 1 tablet 1–2 times a day, no more than 80 mg of drotaverine per day.
4. When using the medicine in injection form, the dosage remains the same. It is not recommended to use injections to treat children under 18 years of age.

special instructions

Specifics of application of No-shpa:

1. When administering the drug intravenously, patients with hypotension should be in a horizontal position.
2. Patients with hypersensitivity to sodium disulfite, asthma and other diseases of the respiratory system are not recommended to use No-shpa injections.
3. Taking Duspatalin does not require any special instructions.

Pregnancy and lactation

Taking No-shpa during pregnancy is permitted if the expected benefit to the mother outweighs the risk to the fetus. It is recommended to avoid injectable forms of the medication.

No-spa can be used during childbirth to shorten the period of cervical dilatation and shorten the overall period of labor, to reduce pain during contractions.

The use of the drug during breastfeeding is unacceptable.

The use of Duspatalin during pregnancy is permitted if the benefit to the mother outweighs the risk to the fetus, and only in capsule form. The medicine can be used during breastfeeding. The dosage during treatment during pregnancy is selected individually. It is unacceptable to self-medicate.

Childhood

Duspatalin is allowed to be given to children over 12 years of age. The medicine is suitable for eliminating discomfort in the gastrointestinal tract, including against the background of psycho-emotional stress and poor nutrition. Both forms of the medicine can be used, but capsules are more suitable.

The use of No-shpa is permissible from 6 years of age. When treating children, the dosage is selected individually. No-shpa can be used to treat children under 6 years of age; in this case, the dosage is calculated based on the child’s weight.

Elderly age

Both drugs can be prescribed to elderly patients.

Side effects of Duspatalin and No-shpa

Adverse reactions from taking Duspatalin:

• dizziness;
• allergic reactions (rashes, swelling).
• Side effects of No-shpa:
• tachycardia;
• hypotension;
• cephalgia;
• dizziness;
• sleep problems;
• nausea;
• fecal retention;
• allergic reactions (swelling, itching);
• anaphylactic shock, including death (frequency unknown);
• reactions at the injection site.

Contraindications to the use of Duspatalin and No-shpa

Taking Duspatalin is prohibited in case of individual intolerance to the components and when treating children under 12 years of age.

Contraindications to the use of No-shpa:

• individual intolerance to components;
• lactase deficiency;
• galactose intolerance;
• hypersensitivity to sodium disulfite;
• liver and kidney diseases;
• heart diseases;
• children under 6 years of age;
• lactation.

The medicine should be used with caution by people with hypertension and women during pregnancy.

Effect on driving

When taking No-shpa or Duspatalin, it is recommended to refrain from driving and engaging in hazardous activities.

Interaction with other drugs

Both drugs are combined with other medications. A doctor's consultation is required.

Alcohol compatibility

Both medications are incompatible with alcohol.

Overdose

Symptoms of Duspatalin poisoning: increased nervousness and excitability. Eliminated by gastric lavage and symptomatic therapy.

Symptoms of No-shpa poisoning: arrhythmia, impaired cardiac conduction, up to cardiac arrest. Hospitalization, symptomatic therapy and treatment aimed at maintaining the functioning of the main body systems are required.

Conditions for dispensing from pharmacies

You do not need a prescription to purchase medications.

Storage conditions

Store away from light and children, at a temperature not exceeding 25 °C.

Best before date

Duspatalin is valid for 3 years, No-shpa - 5 years.

Analogs

Duspatalin 200, Aprofen, Papaverine, Niaspam, Trimedat, Spazmalgon.

Drug price

The average price of No-shpa is 60 rubles (60 mg tablets, 6 pieces) and 100 rubles (5 ampoules of 20 mg/ml). The average price of Duspatalin is 660 rubles (50 tablets of 135 mg) and 530 rubles (30 capsules of 200 mg).

Reviews

Artur Sergeevich, gastroenterologist: “I prescribe Duspatalin as part of complex therapy for irritable bowel syndrome, colitis, Crohn’s disease. The drug does not cure the disease, but it slows down its progression and relieves pain. The drug was well tolerated and I did not notice any side effects.”

Lyudmila Timurovna, pediatrician: “I prescribe No-shpa for children to eliminate pain, spasms, and colic. Sometimes I prescribe it in combination to lower the temperature. The medicine can be given to children, but the dosage must be selected individually and strictly observed.”

Evgeniy Ivanovich, surgeon: “No-shpa always helps out. A universal product with a wide range of uses. The patients did not complain about any adverse reactions.”

Boris, patient: “After treating the ulcer, the doctor recommended taking No-shpa (in combination with other medications) in case of exacerbation. It helps quickly and costs relatively little.”

Ekaterina, patient: “In the last weeks of pregnancy I encountered biliary colic. The doctor prescribed No-shpa and selected the dosage individually. After two days I noticed relief.”

Tatyana, patient: “I treated irritable bowel syndrome in a 12-year-old child with Duspatalin. The medicine is expensive, but effective. The doctor prescribed the treatment.”

Source: https://w.today/zdorove-i-krasota/dyuspatalin-ili-no-shpa

When are medications prescribed?

No-Shpa differs from Duspatalin in its indications for use. It covers a wider range of pathologies.

No-Shpu is prescribed in the following situations:

• spasms of smooth muscles caused by diseases of the bile ducts;
• spasm of the smooth muscles of the urinary tract;
• spasms that cause gastrointestinal dysfunction;
• headache;
• pain during menstruation.

Duspatalin is used:

• with spasms of the digestive tract;
• for intestinal and biliary colic;
• with spastic colitis (irritable bowel syndrome);
• for painful sensations caused by dysfunction of the gastrointestinal tract.

It should be noted that for pancreatitis, Duspatalin and No-Shpa are prescribed to eliminate pain in combination with other medications. The dosage and duration of the course in this case are prescribed by the doctor individually, depending on how the disease progresses.

How do the drugs differ?

Both drugs are myotropic antispasmodics, but differ in the mechanism for achieving results and in the consequences of administration.

The mechanism of action of No-shpa also includes a blockade of the entry of calcium ions into the smooth muscle cell.
By selectively affecting smooth muscle cells, both drugs do not disrupt cholinergic innervation. They are well absorbed from the intestine, undergoing pre-systemic biotransformation to active metabolites. But due to the impact at the level of enzymatic reduction mechanisms

Duspatalin is used in the treatment of discomfort and pain, the source of which is spasm or dyskinesia of the hyperkinetic type of the digestive organs. The greatest effect is observed in the treatment of pathologies of the biliary tract, sphincter of Oddi and large intestine.

For the use of No-shpa, a wider list of diseases is indicated that require an antispasmodic effect:

1. Diseases of the gastrointestinal tract: peptic ulcer of the stomach and duodenum, intestinal and biliary colic, cholecystolithiasis, inflammatory processes accompanied by spastic pain (pancreatitis, cholecystitis, gastroduodenitis, colitis, enteritis, etc.); functional disorders of the digestive organs, incl. irritable bowel syndrome with flatulence.
2. Pathologies of the genitourinary system: urolithiasis, inflammatory diseases (pyelitis, urethritis, cystitis), painful menstruation.
3. Spasm of the blood vessels of the brain, causing headache.

The use of No-shpa during pregnancy to relax the muscles of the uterus (if there is a threat of miscarriage, premature birth, poor opening of the pharynx during childbirth) may be accompanied by hypotonic bleeding, therefore it is only possible under medical supervision.

An important difference between No-shpa is the presence of parenteral forms, this allows the medicine to be used in situations where the pain syndrome is severe (intestinal, biliary or renal colic) or oral administration will be ineffective (for example, due to vomiting).

Administer 1-2 ampoules up to 3 times a day, but not more than 6 ampoules. The duration of treatment is determined by a specialist; it is advisable to use it in short courses with a transition to tablet form.

For oral administration, 1-2 tablets of 40 mg are prescribed 2-3 times a day, but no more than 6 tablets per day (in children over 12 years old and under 12 years old, respectively, no more than 4 and 2 tablets per day). The medicine is taken 0.5 hours before or 1 hour after meals, without chewing, and washed down with water. The duration of treatment is agreed with the attending physician; it is recommended to limit the course to a three-day course without medical advice.

For oral administration, 1-2 tablets of No-shpa 40 mg are prescribed 2-3 times a day, but not more than 6 tablets per day.

Duspatalin is prescribed exclusively orally 20 minutes before meals. Manufacturers offer 2 options: coated tablets and extended-release capsules. The former are taken 3 times a day, the latter – 2. Tablets, like capsules, are not chewed, washed down with water. Unlike No-shpa, this medicine can be taken for a long time (a course of 2 or more weeks).

No-spa acts simultaneously on all smooth muscle cells containing type 4 phosphodiesterase. Therefore, in addition to alleviating spastic pain, undesirable effects of the drug on other organs may occur:

• drop in blood pressure and compensatory tachycardia as a result of dilation of blood vessels;
• headaches, dizziness due to decreased vascular tone;
• constipation due to slow intestinal motility.

In response to taking the medication, allergic reactions and sleep disorders may develop.

When taking No-shpa, side effects are possible, for example, constipation due to slower intestinal motility.

Duspatalin, as an antispasmodic, can cause the same undesirable symptoms, but unlike No-shpa it is better tolerated. It has a narrowly targeted mechanism of action and the likelihood of systemic effects is extremely low. Possible side effects include allergic reactions: skin rash, Quincke's edema, anaphylaxis.

Contraindications

No-spa is metabolized in the liver and excreted in feces and through the kidneys, therefore, with severe dysfunction of these organs, the permissible concentrations of the substance in the blood may be exceeded with the development of a toxic effect. For this reason, the medicine is contraindicated in severe renal or liver failure.

In addition, the medicine can inhibit the activity of the conduction system and cause hypotension, therefore it is contraindicated in heart pathologies characterized by low cardiac output: uncompensated heart failure, 2nd-3rd degree AV block, cardiogenic shock. In healthy people, the drug causes the development of cardiac arrhythmias within 2-3 hours after taking a dose of the drug that is 8-10 times the maximum daily dose.

No-spa can inhibit the activity of the conduction system and cause hypotension, therefore it is contraindicated in heart pathologies characterized by low cardiac output.

Duspatalin does not have such toxic effects and does not affect autonomic innervation. Its instructions for use indicate a general contraindication for prescribing any drug - individual intolerance to the components.

Both medications are used in the treatment of children from 12 years of age. The use of No-shpa in children from 6 to 12 years of age is permitted under medical supervision.

Both drugs do not have embryotoxic or teratogenic effects, but their use during pregnancy must be justified by the predominance of benefits to the mother over possible risks to the fetus. During breastfeeding, it is not recommended to prescribe drotaverine, while mebeverine does not pass into milk.

The use of No-shpa in children from 6 to 12 years of age is permitted under medical supervision.

When to limit your medication intake

Duspatalin is not prescribed for therapy if the patient has a history of hypersensitivity to the composition of the drug.

No-Shpa is prohibited for use:

• in case of hypersensitivity to the components of the product;
• in case of severe impairment of the functional activity of the liver and kidneys;
• with severe cardiac disorders, in particular with low cardiac output syndrome.

The drug should be used with extreme caution if you are prone to hypotension.

As we can see, the difference between No-Shpa and Duspatalin in restrictions on use is significant. Another difference is the minimum age at which these medications can be taken. No-Shpu can be taken by children from 6 years of age, but Duspatalin is approved for use only from 12 years of age. In pediatrics, their analogues, papaverine or trimedate, are most often used to replace these antispasmodics.

Directions for use and dosage

To get rid of pain, adults are advised to take a daily amount of the drug from 120 to 200 mg of drotaverine. The dosage is 3-6 tablets per day and is divided into 2-3 doses.

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Children under 12 years of age are prescribed 850 mg per day. In this case, the dose is divided into 2 doses. If the condition has not stabilized within 2 days, then you need to seek help from a doctor.

Duspatalin capsules are recommended to be taken 20 minutes before meals. Frequency of application: twice a day.

Peculiarities

No-Shpa is produced in the form of tablets and a solution for parenteral administration, this is another difference between the drugs, since Duspatalin can only be purchased in capsules and tablets.

Both drugs can cause side effects such as dizziness and allergic reactions. However, No-Shpa can additionally provoke heart rhythm disturbances. An overdose of this medicine can cause fatal consequences. That is why taking Duspatalin and No-Shpu together is not recommended, since the drugs are part of the same group of medications and taking them together can cause the negative effects of an overdose.

Duspatalin - analogues

Various digestive diseases and syndromes are often associated with severe cramps and pain in the intestines. Duspatalin quickly and effectively helps to cope with them, almost immediately after administration. But sometimes the specified drug has to be replaced due to addiction to it or lack of availability in the pharmacy. In addition, not all people tolerate Duspatalin well - analogues, fortunately, are represented by an extensive list of medications with identical effects and a more reasonable price.

What can replace Duspatalin?

This drug contains one active ingredient - mebeverine hydrochloride. It is a myotropic antispasmodic that has a direct effect on the smooth muscles of the intestine, relaxing it and relieving pain. In this case, the component does not affect peristalsis and does not lead to stool disorders.

The following chemical compounds are considered similar in their mechanism of action:

• trimebutine maleate;
• pinaverium bromide;
• hyoscine butyl bromide;
• Hymecromone.

There are quite a lot of products based on the above ingredients. Among them there are the following analogues of the drug Duspatalin in tablets:

• Trimedat;
• Dicetel;
• Buscopan;
• Odeston;
• Nyaspam;
• No-Shpa;
• Trigan-D;
• Sparex;
• Mebeverine;
• Papaverine;
• Dibazol;
• Trigan;
• Spascuprel;
• Bendazole;
• Meverin;
• Drotaverine hydrochloride.

The first four names are considered the closest to Duspatalin in terms of the method and speed of action, moreover, they are cheaper than the drug described. Let's look at their properties in more detail.

Trimedat or Duspatalin - which is better?

Developed on the basis of trimebutine, Trimedat produces not only an antispasmodic, but also a regulatory effect. The drug helps accelerate gastric emptying and allows you to restore normal intestinal motility in both hyper- and hypokinetic pathological conditions. It quickly eliminates motility disorders and protects smooth muscles from food irritants.

In view of the listed properties, Trimedat can be called a more effective medicine, which eliminates not only intestinal spasms, but also its functional and dyspeptic disorders.

What helps better - Dicetel or Duspatalin?

Dicetel contains pinaverium bromide. This chemical compound reduces the sensitivity of neurons and reduces the severity of pain in the intestines, relieves spasms. In addition, the medication eliminates discomfort caused by functional disorders of not only the intestines, but also the biliary tract, and restores the transit of intestinal contents.

Dicetel, however, does not help with irritable bowel syndrome as well as Duspatalin, but with its help you can effectively treat the symptoms of gallbladder diseases.

Which is better - Duspatalin or Buscopan?

Hyoscine butylbromide, the active ingredient in Buscopan, relieves spasms of smooth muscles throughout the digestive system, including the bile and urinary tract.

The described drug is much more effective than Duspatalin and has a wider list of indications:

• renal, biliary colic;
• pylorospasm;
• cholecystitis;
• dyskinesia of the biliary tract and gallbladder;
• algodismenorrhea;
• exacerbation of peptic ulcer;
• intestinal colic.

Which is better - Duspatalin or Odeston?

Although they have similar effects, the two medications have different purposes. Duspatalin relieves spasms caused by tension in the smooth muscles of the intestines, while Odeston relieves pain associated with insufficient bile production. The latter medication is better if attacks are provoked by hypokinetic biliary dyskinesia or bile hyposecretion. Duspatalin is preferable for intestinal disorders.

Characteristics of Duspatalin

Duspatalin affects the body as follows:

• relaxes and reduces the tone of the smooth muscles of the gastrointestinal tract;
• provides local anesthesia;
• normalizes the volume of water in the intestines.

The use of Duspatalin does not completely suppress the contraction of smooth muscles, so it does not inhibit intestinal motility, does not cause the development of reflex hypotension and does not lead to constipation. The effect after administration develops within half an hour and lasts 12 hours. Duspatalin is indicated for the following diseases of the gastrointestinal tract:

• irritable bowel syndrome;
• colic;
• stomach and duodenal ulcers;
• gastritis, colitis, enteritis;
• gallbladder dysfunction;
• cholecystitis;
• painful movement of stones along the bile ducts;
• after removal of the gallbladder;
• secondary spasms of the digestive organs associated with diseases of other organs.

Treatment of intestinal spasm with Duspatalin has a positive effect on motor function, incl. after cholecystectomy, which is associated with its possible effect on the restoration of the microflora of the small and large intestines.

There are no clinical data on the effect of the drug on children or on the excretion of its metabolites into breast milk. Therefore, it is prescribed with caution to pregnant, lactating women and adolescents under 18 years of age.

Adults tolerate Duspatalin well. Treatment lasts until the spastic pain disappears, on average 2 weeks. More than 90% of the active substance is absorbed in the intestines, and all metabolites are excreted in the urine within 24 hours.

In chronic pancreatitis, Duspatalin helps regulate the functioning of the pancreas, preventing stagnation of secretions; the spasm is relieved by injection of the drug.

Duspatalin capsules contain 32.5% more active ingredient than tablets. They have a prolonged action, releasing the drug throughout their movement through the gastrointestinal tract, which gives good results in the treatment of irritable bowel syndrome.

The drug rarely causes side effects (dizziness, urticaria, facial swelling).