Omez or pariet which is better expert opinion

Pariet and Omez are drugs that are often prescribed by doctors for diseases and disorders of the digestive system. For many years, these drugs have proven their high therapeutic effect. However, choosing one drug from two can be difficult. Pariet or Omez - which is better for treating the digestive system? We have prepared for you a comparative analysis of these funds.

Both of these drugs reduce the secretion of hydrochloric acid in the stomach by reducing the secretion of hydrogen ions. Thus, high acidity is treated and its aggressive effect on the walls of the gastrointestinal tract is reduced, protecting it from the formation of ulcers.

Omez and Pariet - composition

Omeprazole is the active ingredient of Omez. With regular use of the drug, Omeprazole reduces the degree of hydrochloric acid secretion day and night. The rate of development of the therapeutic effect of the drug depends on the dose taken. At the same time, the production of hydrochloric acid is reduced, regardless of the type of damaging agent. This process can be regulated in this way. Omeprazole fights the bacterium Helicobacter pylori. Prescribing the drug together with antibacterial agents in the treatment of gastric and duodenal ulcers helps to normalize gastrointestinal secretion, reduce the risk of developing perforation, penetration and perforation of ulcers.

The active substance of Pariet is Rabeprazole in a dosage of 10 mg or 20 mg. It also inhibits the production of hydrochloric acid, destroys the Helicobacter bacteria, and increases the effect of antibiotics.

Both drugs have antisecretory activity. They concentrate in an acidic environment and inhibit the severity of metabolic processes in the cells of the stomach, due to this the production of hydrochloric acid decreases. This result depends on the dose of the active substance and provides rapid suppression of the natural secretion of hydrochloric acid and secretion caused by the influence of substances.

Although Omez and Pariet are different in composition, they work almost identically.

Advantages of Pariet over similar drugs

The advantage of rabeprazole over its analogues is that it acts on the root cause of heartburn, and does not simply remove the symptom. Heartburn occurs as a result of the reflux of hydrochloric acid into the esophagus. With the participation of Pariet, hydrochloric acid is produced directly in the stomach, without irritating the esophagus.

Compared to other medications, rabeprazole has the following advantages:

• during the first 3 hours: regulation of acid production, effects on parietal cells of the gastrointestinal tract;
• after 3 hours: reducing stomach acidity, maintaining its normal level.
• acid production is blocked for 2 days, there is no reflux of acid into the esophagus;
• During the day, the walls of the esophagus are protected by natural mucus, the secretion of which is stimulated by the drug.

Mechanism of action of drugs

In order to understand which of these drugs is better, it is necessary to understand their mechanism of action.

Omez is an antiulcer agent. It reduces the amount of hydrochloric acid in the stomach. Moreover, it does not matter in what way it is released: natural or stimulated. Omez begins to act after 2 hours.

Pariet works in a wider range of stomach acidity, since its absorption does not depend on the various genetic characteristics of the body. It also suppresses the secretion of hydrochloric acid. The degree of absorption of Pariet from the intestines into the blood does not change depending on the time of meal. The effect after taking the first dose occurs within one hour, and the duration of action lasts about a day. Pariet allows doctors to make reliable predictions about improving the health of patients, and even complete recovery.

When a patient, in addition to problems with the digestive system, has other chronic diseases, he is forced to take appropriate medications. Pariet practically does not interact with medications of various groups. It affects the metabolism of other drugs less than other proton pump inhibitors, and its active component combines well with them. Therefore, when choosing Omez or Pariet, Pariet wins in this comparative characteristic.

These drugs should not be prescribed to yourself, without prior diagnosis and consultation with a doctor. Before using them, it is necessary to exclude the presence of tumor formations in the gastrointestinal tract. Since the initiation of therapy with these medications leads to a smoothing of symptoms and a delay in making the correct diagnosis.

Duration of action

When studying the duration of action of Pariet and Omez, it turned out that there is a difference between them.

Secretory activity occurs more slowly after the end of taking Pariet - after 3 days. When treated with Omez, the release of hydrochloric acid reaches its previous level within 5 days. After finishing taking Pariet, the patient does not face such a problem as “withdrawal syndrome”, that is, a sharp increase in stomach acidity does not occur.

Both products have a bactericidal effect. Their use in combination with antibiotic therapy allows you to quickly eliminate associated symptoms and heal all damage to the gastric and duodenal mucosa. This treatment provides long-term remission of peptic ulcer disease.

Does it make sense to replace Pariet with its analogues: expert opinion

Gastroenterology specialists note that the main disadvantage of the original drug Pariet, compared to analogues, is the high price. Not all patients can afford to take it. In this case, it makes sense to select more affordable generics for replacement. Preparations with similar active ingredients and dosage are recommended. Throughout the entire period of therapy, the clinical picture and the therapeutic effect provided are assessed. If the expected therapeutic effect is absent, the treatment regimen is reviewed and medications with other active substances are selected.

If we compare the effectiveness of Pariet and its analogues, it is necessary to take into account a number of factors in the form of:

• individual characteristics of the patient’s body;
• genetic predisposition to pathologies of the gastrointestinal tract;
• degree of development of the disease;
• the presence of associated complications;
• inclusion of other groups of drugs in the treatment regimen.

To select the correct dose of Pariet or its analogue, pH testing is recommended. This study determines the sensitivity of the stomach to the dosage of the active component.

Form of release of drugs and price

Omez is available in hard transparent capsules with an enteric coating. One capsule contains 20 mg of Omeprazole. Each tablet is marked "OMEZ" in black. A box contains 30 capsules, packaged in aluminum strips of 10 pieces.

The dosage form of Pariet is tablets that have an enteric coating and a round shape. The 10 mg tablets are pink in color and marked “E241” on one side. As for the tablets containing 20 mg of Rabeprazole, they are light yellow and labeled “E243”. One package can contain 7, 14 or 28 tablets.

The prices of these medications vary. It depends on the cost of manufacturing the active substance, on the company and country of manufacture, etc. etc.

Pariet is more expensive than Omez. The cost of the first varies in a wide range of prices: from 800 to 3,700 rubles. This difference is due to the dosage of the medicine; the higher it is, the higher the price. Omez has a significant advantage in terms of price and is ahead of its opponent: the price varies from 100 to 500 rubles.

What is Nexium

Russian drug of the group of proton pump inhibitors. The active ingredient is esomeprazole, an isomer of omeprazole. The therapeutic effect of the substance lies in its ability to suppress the formation of gastric acid by inhibiting the proton pump in specific gastric cells.

The substance exhibits weak properties, but after entering the acidic gastric environment it is sharply activated: the antiulcer effect develops within an hour after administration and reaches maximum values ​​after two, lasting for 17-24 hours.

Nexium is recommended for use in:

• GERD
• PUD/duodenum
• Conditions of the gastrointestinal tract due to the use of NSAIDs (healing of ulcers, prevention of exacerbations of peptic ulcer disease)
• Zollinger-Ellison syndrome and other conditions that occur against the background of hypersecretion of hydrochloric acid.

The drug is produced in pellets, granules and tablets coated with an enteric layer, as well as in the form of a lyophilisate to reconstitute the injection solution.

Contraindications:

• Individual intolerance to components
• Congenital fructose intolerance, GG malabsorption syndrome, sucrose/isomaltose deficiency in the body
• Age up to 12 months, weight less than 10 kg
• Therapy with Atazanavir, Nelfinavir.

Possible side effects:

• Individual allergies
• Skin reactions such as rash and itching, hair loss, Lyell's or Stevens-Johnson syndrome
• Pain in muscles, joints
• Weakness
• Dizziness, headaches
• Gastrointestinal disorders, liver disorders, hepatitis
• Depression, excitability
• Hematopoietic disorders
• Bronchospasm
• Deterioration of vision
• Peripheral edema.

Caution is required when prescribing to patients with severe forms of renal hypofunction.

Indications for use of Omez and Pariet

The areas of application of both drugs are almost the same, but there are still some differences.

1. Both Omez and Pariet are prescribed for stomach and duodenal ulcers. Both are used during periods of exacerbation.
2. The drugs are used to treat gastroesophageal reflux disease (GERD). It has been proven in clinical settings many times that rabeprazole in Pariet is much more effective in fighting the disease, especially in older people. Such patients experience more severe damage to the esophagus. Due to its long-lasting effect, Pariet blocks the final stage of hydrochloric acid production in the stomach, and during this time, partial scarring of the stomach tissue occurs.
3. Both drugs are prescribed for the treatment of a condition characterized by pathological, impaired hypersecretion (Zollinger-Ellison syndrome, multiple endocrine adenomatosis, including systemic mastocytosis).
4. Omez, unlike Pariet, is often used to combat stress ulcers and stomach disorders caused by non-steroidal anti-inflammatory drugs (Aspirin, Ibuprofen, Nabumetone, etc.).
5. Omez and Pariet are used in combination with antibacterial drugs according to a specific scheme to destroy Helicobacter pylori.
6. Pariet is prescribed for the treatment and protection against relapses of peptic ulcer disease caused by the Helicobacter bacterium. This drug is also used to destroy pathogenic bacteria in patients with chronic gastritis.

Only a gastroenterologist understands the subtleties of the differences in indications for the use of both drugs. Omez and Pariet, although they are similar in indications, any, even insignificant, difference can lead to serious consequences.

Omez: characteristics

The active ingredient is omeprazole , which can actively eliminate the symptoms of high acidity and unstable gastrointestinal tract function. Available in the form of capsules and powders for preparing solutions. Proton pump inhibitor prevents the production of excess hydrochloric acid. The effect after use occurs quickly (no more than an hour) and persists throughout the day. If you stop taking it, enzyme function is restored within a few days.

Application area:

• Treatment of ulcerative lesions.
• Used in complex therapy of inflammatory processes in the gastrointestinal tract.
• As a prophylactic.

It can be used during pregnancy, since studies have not shown any negative effects during fetal development, but it should only be taken as prescribed by a doctor. During breastfeeding it is recommended to stop using it.

Mode of application

Omez belongs to the first generation drugs, and Pariet is already a fourth generation drug. That is why the high clinical effectiveness and normalization of the patient’s condition, rapid and reliable relief of symptoms with the second drug are better than with the first. In this case, this is the advantage of Pariet.

To achieve improvement, Pariet must be taken in a smaller dosage than Omez. The active ingredient Pariet rabeprazole immediately enters the circulatory system as an active compound, so it begins to act much faster. Due to this, it is less susceptible to metabolism in the liver, and the drug is well tolerated by patients. The positive effect of Omez and Omeprazole is achieved only after its activation in hydrochloric acid.

How much to take

For duodenal ulcer during exacerbation:

• Omez take 1 tablet per day, 2-4 weeks;
• Pariet is taken in the morning, 1 tablet per day, for 4-6 weeks.

For stomach ulcers during exacerbation:

• Omez - 1-2 capsules for 6-8 weeks;
• Pariet - 1 tablet in the morning, course - 4-6 weeks.

To destroy the pathogenic Helicobacter:

• Omez 1 capsule twice a day + antibacterial therapy;
• Takes 1 tablet twice a day + a combination of antibiotics.

In each individual case, the dosage of medication is determined by the attending physician.

Description of Pariet

Pariet contains rabeprazole and is produced in tablet form by the Russian manufacturer Johnson{amp}amp;Johnson. This is an antiulcer medicine that inhibits acid secretion. Tablets include 10 and 20 mg of the component.

Rabeprazole is an antisecretory substance. It suppresses acid production at the final stage. The antisecretory effect appears within an hour from the moment of administration. The action lasts 2 days. After discontinuation of the drug, secretory function is restored on the second day.

When comparing the effectiveness of Pariet with drugs based on omeprazole, it was found that the former eliminates heartburn more effectively and quickly. After 4 weeks of taking 10 mg of Pariet, the symptom was eliminated in 65%, treatment with omeprazole showed a result of 50%.

It is made on the basis of esomeprazole. Available in 20 and 40 mg. Manufacturer: AstraZeneca. The drug is classified as a PPI.

Esomeprazole reduces acid secretion by inhibiting PN. The action develops within an hour. Its use for 4 weeks at 40 mg leads to healing of esophagitis in approximately 78% of patients.

Contraindications

General contraindications for these medications are:

• pregnancy period;
• breast-feeding;
• intolerance to drug components.

Omez is not prescribed to children under 4 years of age and weighing less than 20 kg. There is no data on the effect of Pariet on the children's body.

Side effects

After taking both drugs, you may experience:

• disorders of the digestive system (constipation, diarrhea, dry mouth, nausea, vomiting, etc.);
• disturbances in the functioning of the nervous system (headache, insomnia, dizziness);
• allergic reactions (rashes, swelling);
• other effects (visual impairment, lack of taste, etc.).

The list of these side effects is for informational purposes only. Typically, the effects of both Omez and Pariet are well tolerated by patients. If side effects occur, they are short-term and passing.

When choosing a drug, be guided by its spectrum of action and severity of side effects. Omez and Pariet are similar products in this regard. They have approximately the same effect on the gastrointestinal tract and have the same side effects. The most significant difference between these drugs is only in price. However, we advise you not to experiment and seek help from a competent gastroenterologist. He knows exactly which medicine is right for you.

How is Pariet used?

The main effect is to reduce stomach acidity, which helps recovery.
The analgesic effect helps you feel relief in minutes. Despite the high effectiveness of the drug, people are more often looking for analogues, because the price of the drug in Russia starts from 780 rubles.

Release form: round, coated tablets. Its effect occurs much faster than that of Omez.

Pariet is great for heartburn. The medicine is compatible with some antibacterial drugs aimed at eliminating infections in the gastrointestinal tract. In addition, the almost complete absence of side effects makes it a leader among similar drugs.

Contraindications for use may be:

1. The drug is prohibited for children under 12 years of age.
2. Kidney failure makes taking the medication impossible.
3. It is prohibited to choose or increase the dosage yourself.
4. Failure of the body to accept certain components of the product.
5. Pregnancy and lactation are periods that you should not take Pariet.

The harmfulness of the last point has not been definitely proven, but it is known that the components of the drug reach the baby through breast milk.

The opinion of experts about Pariet is only positive, because it has been proven to have the ability to remove components from the body and slow down metabolism. In case of overdose, you must urgently rinse your stomach. It does not have strong effects, so it is easily tolerated by the body.

It has no harmful effect on all body systems. When using the tablets, you should not chew them. Taken in the morning before meals.

In general, taking the medicine is allowed at any time, but in the morning the effect will be much stronger. Despite its positive characteristics, it has few side effects. If you increase the dosage of the tablets yourself, calcium is removed from the body, which increases the risk of bone fractures. Therefore, self-medication with this remedy is strictly prohibited. The medicine has more than one positive review, even despite the high price.

When used, the patient may experience side effects.

These include:

• diarrhea;
• constipation;
• weakness;
• nausea;
• dry mouth;
• skin rashes.

Proton pump inhibitors are considered the main drugs for the treatment of various ulcerative diseases. The products Omez and Pariet have become very popular. They have similar action characteristics (they block the proton pump in the lining of the stomach).

Active components reduce acidity and have a restorative function. The characteristics of the medications are almost identical, but there are differences that provoke the peculiarities of their use depending on the patient’s condition, as well as on the course of the disease.

https://www.youtube.com/watch?v=BAXN8Q7n5Ek

Despite the high effectiveness of the drug, people are more often looking for analogues, because the price of the drug in Russia starts from 780 rubles.

It has no harmful effect on all body systems. When using the tablets, you should not chew them. Taken in the morning before meals.

List of Pariet analogues with average prices in Russia

Cost of Pariet in pharmacies in December 2021:

1. Tablets 10 mg (7 pcs.) – 930 rub.
2. Tablets 10 mg (14 pcs.) – RUB 1,460.
3. Tablets 20 mg (14 pcs.) – RUB 2,060.
4. Tablets 20 mg (28 pcs.) – RUB 3,660.

The drug has exact structural analogues from other manufacturers, some of them with a more affordable price:

1. Zulbex 10 mg (28 pcs.) – 840 rub.
2. Beret – 500 rub.
3. Khairabezol 10 mg (15 pcs.) – 400 rub.
4. Noflux – 760 rub.
5. Razo – 10 mg (30 pcs.) – 330 rub.
6. Losek – 290 rub.
7. Rabeprazole-SZ 20 mg (28 pcs.) – 310 rub.
8. Rabeloc 20 mg (14 pcs.) – 450 rub.
9. Ultop – 110 rub.
10. Rabiet 20 mg (28 pcs.) – 600 rub.
11. Dexilant – 1,080 rub.

If it is necessary to select a replacement, it is recommended to first consult a doctor.

The cheapest generics of the drug

The cheapest analogues of Pariet based on the active substance:

• Khairabesol (India).
• Razo (India).
• Rabemak (India).
• Rabeprazole-SZ (Russian drug).
• Rabimak (India).
• Barol (India).
• Rabelok (India).
• Rabeprazole from the company Zdorovye (Ukraine).

When selecting a replacement, agree on the dose of the medicine, frequency and duration of its use.

Main features of the pharmacokinetics and pharmacodynamics of omeprazole

When taken orally, this drug is quickly absorbed from the digestive tract, binds to blood plasma proteins in a volume of about ninety percent, but due to metabolic changes in the liver, the bioavailability of the drug does not exceed forty percent.

The drug quickly undergoes metabolic changes in liver cells - the half-life of omeprazole is half an hour to an hour with normal liver and kidney function. It is important to consider that if the patient has liver failure, the bioavailability of the drug tends to be one hundred percent, and the half-life extends to three hours.

In people with renal failure, the rate of drug elimination is directly related to the decrease in creatinine clearance.

This drug inhibits one of the enzymes necessary for the synthesis of hydrochloric acid by the parietal cells of the stomach, namely sodium-potassium ATPase. At the same time, the last stage of hydrochloric acid production is blocked, due to which both basal and stimulated secretion is reduced.

In this case, the effect of taking the drug occurs in about an hour and lasts up to a day (with a stable decrease in acidity to three within seventeen hours). Sometimes the so-called rebound phenomenon is possible, although this occurs relatively rarely.