Mezim or pancreatin which is better for pancreatitis

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• Health

— 31.10.2017 31.10.2017 0 10023

In recent years, a situation has developed that people cannot take a single step without various kinds of pills. And to a greater extent this applies to stomach pills. And this is initially due to the fact that the so-called fast food is very developed in the world. Frequent use, which leads to various types of stomach upsets.

Therefore, in order to help their stomach, people resort to medications for help. And in this case, one of the most common drugs, surprisingly, is Pancreatin and the well-known Mezim. But this is not the entire list of possible drugs. But what is better to use and in what cases? This is what we will try to figure out.

Indications for use of Pancreatin

The drug belongs to the group of drugs that compensate for the deficiency of pancreatic enzymes. Applicable in the following cases:

1. chronic pancreatitis, cystic fibrosis and other conditions accompanied by impaired and insufficient functioning of the pancreas, deficiency of necessary enzymes;
2. diseases of the gastrointestinal tract, inflammatory-dystrophic nature;
3. diarrhea, dyspeptic disorders, flatulence, indigestion;
4. postoperative period, rehabilitation after radiation;
5. elimination of unpleasant symptoms (heaviness, abdominal pain, flatulence) caused by overeating, changes in usual food, lifestyle, impaired chewing function, insufficient physical activity or inactivity;
6. preparatory stage before examinations, ultrasound and surgery.

The medicine should be taken during or after meals three times a day if pancreatic function is impaired. The tablets must not be chewed. If you are concerned about heaviness and pain in the abdomen due to overeating, a sedentary lifestyle and other factors, the medication can be taken once.

The course depends on the indications and varies from 2 days to several years.

The medicine is used in pediatrics and to treat adults. The dosage, frequency of administration and course are determined by the indications.

Restrictions on use – acute form and exacerbation of chronic form of pancreatitis, individual intolerance. The drug is safe.

Undesirable effects include allergic reactions and, with long-term use, a decrease in the secretory function of the pancreas.

Brief description of the drug Mezim

Before giving preference to any particular drug, it is worth understanding what it is. So, Mezim is, first of all, one of the most popular drugs that belong to the so-called broad pharmacological group. The main component of this drug is pancreatin. It is this that ensures the effect of the pill directly on the body.

Pay attention to the fact that this drug not only helps the stomach cope with fatty foods, but also helps normalize the digestion process. The effect of Mezim appears within half an hour after you take the pill. In addition, this drug includes a number of enzymes, which in turn additionally relieve the burden on the stomach.

Remember, it is strictly forbidden to take Mezim for people who have a disease such as pancreatitis. Therefore, if you have such a disease, the best solution would be to use some other drug with similar actions. Sometimes, after taking Mezim, so-called side effects may occur (nausea, heaviness in the stomach, stool disturbances). Most often, such symptoms occur after excessive use of pills.

Mezim or Pancreatin - which is better, reviews?

Reviews for these medications are mixed. Many patients prefer Mezim, since it is a more advertised product from a European manufacturer. Others point out that Mezim is not more effective than Pancreatin, but the latter is much cheaper. There is also a third party: patients who believe that it is better for children, pregnant women and nursing mothers to buy Mezim, since it is safer, and everyone else can safely use Pancreatin.

People who have taken both drugs note that they are both quite effective, but Pancreatin begins to work more slowly. It is better to drink it in a course, but with a single dose (for example, if you break your diet), it has a weaker effect.

Mezim better relieves bloating, nausea, heaviness in the abdomen, and diarrhea, but has a lesser effect on pain.

To summarize, we can highlight the following positive and negative points for each of the drugs.

Pancreatin

• affordable price;
• variety of dosages;
• good tolerance.

• slow start to work;
• lower quality of raw materials.

Brief description of the drug Pancreatin

But Pancreatin is, first of all, a drug that replenishes the deficiency of so-called enzymes. And it is prescribed not only for such a disease as pancreatitis, but in many other cases. For example, this drug can be used for gastritis, dispersion, cirrhosis, cholecystitis or flatulence. And this is not the entire list of possible diseases for which it would be advisable to use this drug.

Pancreatin contains enzymes that allow your stomach to fully digest food. Please note that doctors do not recommend using this drug during pregnancy. It should also not be given to children under three years of age.

The main active ingredient in the drug is pancreatin (but only of pork origin). Therefore, people who are very poorly able to tolerate this component, taking a Pancreatin tablet, can provoke an allergic reaction.

Directions for use and dosage

Mezim Forte is prescribed to adults and children over 3 years of age. You can take 1-2 tablets with meals. Do not chew; it is recommended to take plenty of liquid. If replacement therapy is carried out, then 2-4 capsules per day are indicated.

We recommend reading: What to choose: analgin or citramon

Mezim is prescribed 1-2 tablets per day. Do not exceed a dose of more than 15-20 thousand units of lipase per 1 kg of weight.

The duration of the treatment course ranges from 2 weeks to several years.

Pancreatin in capsules, dragees and tablets is intended for internal use. Taken with meals. The medicines are swallowed whole and washed down with 100 ml of warm water. The daily dosage should be divided into 2-3 doses. The dose depends on the indications and age of the patient. In case of overeating and heaviness in the stomach, you should take 1-2 tablets of Pancreatin.

What is the difference between Mezim and Pancreatin?

As mentioned earlier, due to the fact that modern people consume fatty foods in large quantities, they experience a feeling of heaviness and stomach problems. Therefore, to make your life easier, you have to use various drugs. Which help get rid of such unpleasant symptoms.

Despite the huge range of medicines, Pancreatin or Mezim are increasingly used in such cases. But what is the best drug to choose? Getting an answer to this question is not so easy. Because a lot depends on the situation. And in this case, you cannot do without consulting a doctor. Moreover, these drugs are not as similar to each other as it seems at first glance.

The first and most important difference between these drugs is the country in which the drug is produced. There is also a significant price difference between these drugs. Mezim costs three times more than Pancreatin. You also shouldn’t lose sight of the difference in enzyme parameters.

What is the difference between Mezim and Pancreatin?

Regular digestive problems and a constant feeling of heaviness in the stomach after a fatty meal make it necessary to take special medications with digestive enzymes. Medicines can eliminate unpleasant symptoms such as nausea, heaviness, bloating, and flatulence. The drugs help stabilize the functioning of the intestines and other digestive organs, and get rid of stagnation in the intestines from overeating. The modern range of enzyme preparations of domestic and foreign production is wide, so choosing one, but effective, is difficult. Many people prefer to take Mezim and Pancreatin. You need to figure out if there is a difference between them, and what are the features of each medication?

What to choose?

Due to the rapid development of radio and television, one can often find advertisements for various medical drugs. And medications such as Mezim and Pancreatin are no exception. There are a lot of them and they are often advertised. Therefore, most people, having seen this kind of advertising, ask the same question: which is better, Pancreatin or Mezim, or maybe they are the same thing, only the names are different?

To fully reveal the answer to this common question, these two drugs just need to be compared with each other.

So, Pancreatin uses enzymes from so-called pork material, and Mezim uses enzymes from cattle tissue. Mezim does not have such a strong effect, so most often it is used exclusively after overeating. But Mezim Forte has a stronger effect, so it may well compete with Pancreatin.

Typically, Pancreatin is used only after a doctor’s prescription, but this rule most often does not apply to Mezim, since in most cases it can be taken independently without a doctor’s recommendation.

But in addition to their differences, these drugs also have similar properties. For example, it is strictly forbidden to use them for any diseases related to the stomach and pancreas. It is also advisable to use both of these drugs in the presence of a lack of so-called enzymes.

As for the well-known prefix Forte, in both cases it means that the drug has a stronger effect.

In addition, a distinctive feature of these medicines is the country in which they are produced. For Mezim, this is Germany, but Pancreatin, as you know, is a so-called domestic medicine.

Remember, both of these medications belong exclusively to the preventive group of medications. It is also worth noting that, if necessary, these medications can perfectly replace each other. Because they all have a fairly similar effect.

But I would still like to remind you that if you find yourself experiencing pain in the abdominal area, you should not drop everything and run to the pharmacy for a pill. After all, the problem may turn out to be much more serious than it seemed to you at first glance. And taking the “wrong” drugs can cause quite a lot of harm to your body. Therefore, the first thing to do if any painful sensations occur is to seek help from a qualified doctor. He will conduct a full examination of your body and explain in detail what causes the pain, as well as how to get rid of it.

Therefore, you should not buy the first remedy that comes to mind for the symptoms that arise. After all, your health is at stake, and you need to take care of it.

With the modern rhythm of life, in conditions of constant stress and the frequent inaccessibility of healthy nutrition, gastrointestinal diseases become a regular evil and well known to each of us. Parties and feasts, spicy and fatty foods, overeating and low-quality products actively contribute to your gastrointestinal tract leaving your comfort zone.

To support the failing organs of the gastrointestinal tract, scientists have developed many enzyme preparations. From this wide list in Russia, the most popular brands remain “Mezim” and “Pancreatin what is it”. This article will help you decide which is better, Pancreatin or Mezim or Creon, which is better, understand the strengths and weaknesses of each of them, and understand which drug is best for you.

When are medications prescribed?

Enzymatic drugs are good for gastric dysfunction associated with insufficient production of pancreatic enzymes.

Mezim is prescribed for:

• enzyme deficiency;
• eating large amounts of fatty foods;
• chronic pancreatitis;
• radiation therapy after surgery on the gastrointestinal tract;
• digestive disorders of infectious origin;
• IBS (irritable bowel syndrome);
• in preparation for an x-ray or ultrasound of the abdominal organs;
• stagnant processes in the intestines;
• bloating.

Indications for the use of Pancreatin are:

• chronic hepatitis or cholecystitis;
• chronic form of pancreatitis;
• binge eating;
• inflammatory processes in the gastrointestinal tract;
• diarrhea of ​​non-bacterial etiology;
• preparation for ultrasound or x-ray of the gastrointestinal tract.

Comparison of drug indications

The indications for the use of these two drugs are not too different. Mezim differs from Pancreatin in its effect on these diseases. Since Pancreatin contains fewer active substances, it is prescribed for milder forms of enzyme deficiency, gastrointestinal diseases of mild or moderate severity. Mezim has a prolonged therapeutic effect, so its use can be reduced to one dose per day.

“Mezim”: indispensable for the stomach?

One of these drugs, Mezim, which is well known to many of us, belongs to the pharmaceutical group of enzyme preparations. It has a therapeutic effect due to the pancreatin contained in it. Thanks to Mezim, fats, proteins, and starch are better broken down in the gastrointestinal tract.

Improving digestion

This normalizes the functioning of the small intestine. In addition, a number of enzymes will reduce the load on the pancreas. Mezim exhibits maximum activity 30 minutes after administration.

In particular, under no circumstances should it be used in case of pancreatitis or allergies to the components of the drug.

Like many other medicines, Mezim can also cause side effects. In particular, we are talking about allergies, nausea may appear, as well as problems with stool.

Description of Mezim and Pancreatin

The main component of Mezim, which determines its effect on the body, is pancreatin, which has an amylolytic, proteolytic, and lipolytic effect. An enzyme isolated from animal tissue helps break down fats, proteins and starch into fatty acids, glycerol, amino acids, mono- and dextrins. As a result, the digestive system normalizes its functioning, the broken down nutrients are better absorbed in the small intestine, and the load on the pancreas is removed. The maximum enzyme activity of Mezim occurs 30 minutes after taking the tablet. The drug is indicated for use in gastrointestinal disorders caused by:

• exocrine dysfunction of the pancreas;
• reflex failures of the cardiovascular system;
• postoperative syndrome after removal of a glandular organ followed by irradiation;
• general condition after removal of part of the intestines, stomach;
• cystic fibrosis;
• diarrhea of ​​non-infectious nature;
• diet disorders;
• overeating.

• with acute and aggravated pancreatitis;
• in case of excessive sensitivity to the components of the drug;
• with allergies to medications.

Long-term treatment with Mezim is fraught with hyperuricosuria and hyperuricemia. If any side effects are detected, the drug should be discarded.

Mezim affects the absorption of iron, so during long-term therapy you need to take medications containing iron at the same time as it.

The main feature of Pancreatin is to replenish the deficiency of digestive enzymes. The product contains lipase, protease, amylase, which help ensure the complete breakdown of pine products into useful microelements that are easily absorbed by the body. The medicine supports the healthy functioning of all digestive organs.

The drug is indicated for use in acute, acute and chronic pancreatic disorders. The drug is also taken in cases of diagnosing:

• gastritis, duodenitis;
• atrophic changes in the gastrointestinal tract;
• dyspepsia;
• non-infectious gastrointestinal diseases;
• fibrosis, cirrhosis, necrosis of the gastrointestinal tract;
• functional diarrhea;
• cholecystitis;
• increased flatulence.

Pancreatin is prescribed for constant overeating, harmful gastronomic addictions, and before diagnosing the condition of the digestive organs. The active ingredient in the drug is of animal origin, so an allergy may be a side effect from use. The drug is contraindicated in case of lactose intolerance, acute course and exacerbations of pancreatic inflammation in the gastrointestinal tract. Dosages for the treatment of drugs for gastrointestinal disorders in cystic fibrosis are selected with caution.

Mezim tablets have this appearance.

If Mezim or Pancreatin additionally uses the prefix “forte” in the name, it means that the tablets are covered with a durable coating that prevents the drug from prematurely dissolving in the gastric juice. Consequently, the tablet reaches the small intestine in its original form, where enzymes are activated in an alkaline environment. After performing its function, the active substance is digested and excreted from the body.

Both drugs are not recommended for use during pregnancy and lactation, or for children under three years of age. But in cases of justified risk, the attending physician may prescribe any of these remedies. According to some points in the instructions for both drugs, you might think that they are the same drug.

"Pancreatin": what is it and what is it eaten with?

"Pancreatin" is also an enzyme preparation. It includes enzymes such as lipase, protease and amylase. They help normalize digestion and support healthy gastrointestinal function.

Pancreatin for digestion

If the name of the drug contains the prefix “Forte”, this means that it is equipped with a shell that is resistant to the caustic environment of gastric juice, which protects enzymes until they are delivered to the target part of the intestine.

There, in the alkaline intestinal environment, their active action begins, after which they are digested.

Doctors do not recommend taking Pancreatin during pregnancy, but this is permissible if problems with the gastrointestinal tract can pose a serious threat to the health of the mother and child. Also, the drug is not recommended for children under three years of age and people suffering from acute chronic pancreatitis or acute pancreatitis.

Please note that the drug contains pancreatin of animal origin, which may cause allergic reactions in sensitive patients. Pancreatin is also contraindicated for people who are lactose intolerant.

Pancreatin or Mezim: which is better, is it the same thing or not, what is the difference between drugs for pancreatitis?

The main active ingredient in this drug is pancreatin, an extract from the pancreas of livestock. It is prescribed to patients in the following cases:

1. Impaired pancreatic function, including diseases such as cystic fibrosis, chronic pancreatitis, Roemheld syndrome, etc.;
2. Problems with the absorption of food, including after a resection, as well as when eating excessively heavy or exotic foods;
3. Intestinal infections;
4. Diseases of the liver, gall bladder and biliary tract, including those of a chronic nature;
5. Preparation of the gastrointestinal tract for clinical studies.

The drug contains enzymes such as lipase, protease and amylase, which are necessary for the body for the normal process of digestion and absorption of proteins, fats and carbohydrates.

Sometimes the word “Forte” appears in the name of the drug; such tablets are coated with an enteric coating that is resistant to the action of gastric juice. The fact is that pancreatin, upon contact with the acidic environment of the stomach, loses all its beneficial properties and becomes completely useless.

There are a number of contraindications to taking Pancreatin. For example, it should absolutely not be used by young children under two years of age, those with acute pancreatitis and those in the acute stage of the chronic form. The drug is not recommended for pregnant women, since the safety of the drug for the unborn child has not been proven. However, in some cases, the attending physician may include it as part of the therapy.

In addition, there is a risk of allergies; the drug should not be taken by people intolerant to lactose and pork.

Long-term use of large doses of the drug can cause malfunctions in the body, so the attending physician should prescribe treatment with Pancreatin. When taking the medication, you should not violate the indicated doses and duration of administration in order to avoid side effects of the drug.

One of the most famous drugs belonging to the enzyme group in popular circles is Mezim.

The main active ingredient of this medicine is also pancreatin, thanks to which Mezim helps to normalize the process of fat breakdown and absorption of substances in the small intestine. As a result, the digestive process improves.

Due to the presence of other enzymes in the composition, excess load is removed from the pancreas. The effect of the drug begins approximately half an hour after administration, when the enzymes enter the intestines.

The wide spectrum of action of Mezim allows it to be prescribed for the following diagnoses:

1. Pancreatic dysfunction: exocrine insufficiency;
2. Renhed's syndrome;
3. Therapy after interventions and radiation;
4. Cystic fibrosis;
5. Non-infectious diarrhea;
6. Overeating, excess food that is too heavy for the stomach.

Like any medicine, Mezim has a number of contraindications. These include acute pancreatitis, an exacerbation of the chronic form of the disease. In addition, those who have allergic reactions or hypersensitivity to the components of the drug should not take Mezim.

Side effects from taking Mezim may include allergies, stomach pain, and diarrhea. With long-term use of large doses of this drug, symptoms of hyperuricosuria and hyperuricemia may appear. In this case, the drug is stopped and therapy is prescribed.

Another side effect of Mezim is a decrease in iron absorption. Therefore, when prescribing a long course of treatment, iron supplements are prescribed as maintenance therapy.

Here are more detailed instructions for using Mezim

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Which drug is better to choose

When faced with malfunctions of the digestive system, the average person rarely consults a doctor. The fact is that indigestion, if it is not accompanied by other, more serious symptoms, is considered to be a problem not worthy of attention.

Usually a person, trusting advertising or reviews of other people, goes to the pharmacy and buys the drug on his own, based on the capabilities of his own wallet and the “knowledge” imposed by advertising.

And here the question may arise, what is better, the more budget-friendly, but domestic “Pancreatin” or the less cheap, but German “Mezim”.

However, before you start taking any enzyme preparation, you should consult your doctor.

The fact is that the drugs differ in composition and quantity of active enzymes, and only a specialist is able to determine what dose is needed for a given patient.

We should not forget that long-term use of an inadequate dose of both “Pancreatin” and “Mezim” can cause serious health problems, the treatment of which can be lengthy and very costly.

• Most often, Pancreatin is prescribed to people with minor gastrointestinal problems, since the content of enzymes in it is relatively low.
• "Mezim", as a rule, is prescribed in more severe cases indicated in the indications for use, since its action is more effective. However, if medical examinations reveal serious diseases of the digestive system, the doctor will most likely prescribe complex therapy using potent drugs.

To summarize, it is worth emphasizing once again that you should not self-medicate and buy any enzyme group drugs without first consulting a doctor. It is a competent specialist who must determine which drug will be more effective in this particular case: “Pancreatin” or “Mezim”.

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To find out the difference between mezim, festal, pancreatin and creon and to understand the differences between festal and mezim or pancreatin and festal, let's take a look at the composition tables of these drugs.

It is impossible to say that Mezim, Pancreatin, Festal or Creon is better, because it depends on the state of the body of each person individually. Here, just by looking at the tables, you can compare the difference between Mezim, Pancreatin, Festal and Creon just to understand the strength of these drugs.

Festal composition table

Lipase is necessary for the digestion of fat, Amylase is necessary for the digestion of carbohydrates, Protease is necessary for the digestion of proteins, and pancreatin consists of lipase, amylase, and protease.

So, from the tables it is clear that the most powerful enzymatic drug for pancreatitis is:

1. Creon 25000
2. Creon 10000
3. Mezim forte 10000
4. Festal
5. Mezim forte
6. Pancreatin

This does not mean that pancreatin is the worst medicine. On the contrary, the weaker the disease, the weaker the medicine we use.

Which medicine is best for whom, and in what doses, is an individual question that is best decided with your doctor.

That's basically it. I just wanted to show the difference between enzymatic drugs for pancreatitis.

More on this topic:

1. How to take Creon 25000 for pancreatitis
2. Creon is used for pancreatitis.
3. How to take enzymes correctly for pancreatitis
4. When and how to take pancreatin

If you think that the article is really interesting and useful, then I will be very grateful if you share this information with your friends on social networks. To do this, simply click on the social media buttons.

Best regards, Alya.

ul

Creon

The medication is sold in the form of capsules containing pancreatin. According to the instructions, it is recommended to take it for:

• Cancer or inflammation of the pancreas.
• Enzyme deficiency.
• Disorders of the gastrointestinal tract in the elderly.
• Cystic fibrosis.
• Removal of the pancreas, etc.

In addition, the medicine is prescribed to improve digestive processes, during surgical operations on the stomach, for intestinal pathologies, liver cirrhosis, dysbacteriosis, cholestasis, etc.

The medication has contraindications. It should not be taken during exacerbation of pancreatitis. To exclude the possibility of intestinal damage, treatment should be carried out under the supervision of a doctor. He determines the course of the disease and prescribes the necessary dosage. Capsules are taken simultaneously with food.

The medication has side effects, but they occur infrequently. Nausea, pain in the gastrointestinal tract, and loose stools occur extremely rarely.

The cost of the drug depends on the dosage. 20 capsules of Creon 10000 at a dosage of 150 mg cost about 300 rubles.

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Mezim

The medication is available in the form of tablets based on pancreatin, an animal enzyme.

Mezim is prescribed:

1. For chronic diseases of the genitourinary system.
2. During the recovery period after operations on the gastrointestinal tract.
3. For digestive disorders.
4. With forced immobility.
5. Before conducting diagnostic studies, etc.

The tablets are contraindicated for pregnant women, acute pancreatitis and a number of other cases. The drug may cause allergic skin rashes. In this case, it is recommended to interrupt treatment and consult a doctor for help.

The tablets are taken before meals with a sufficient amount of alkaline liquid (juices, water). They cannot be chewed.

Mezim causes the following adverse reactions:

• Heaviness in the gastrointestinal tract.
• Spontaneous emptying of the stomach.
• Problems with stool.
• Skin rashes.

In rare cases, an increase in uric acid levels cannot be ruled out.

The cost of 20 tablets of Mezim Forte 10000 starts from 178 rubles.

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Source: https://diabetystop.com/preparati/pankreatin-ili-mezim-chto-luchshe-eto-odno-i-tozhe-ili-net-v-chem-otlichie-preparatov-ot-pankreatita/

If you can't see the difference

Let's see if there is a difference between these drugs? At first glance, they are identical; they are based on one substance – pancreatin. They both have approximately the same indications, and the same thing is also indicated in the “side effects” column.

Difference between Mezim and Pancreatin

However, there is still a difference.

Firstly, this country is produced by the Germans, in turn, “Pancreatin” is produced in the territory of the post-Soviet territory.

Secondly, the price also differs: for 20 tablets of Mezima you will have to pay about 90 rubles, while Pancreatin has a relatively low cost - three blisters of 20 tablets will cost about 35 rubles.

The main differences lie in the numerical expression of the minimum enzyme activity. Mezima boasts 3500 units of lipase, 250 units of protease and 4200 units of amylase. “Mezim or Mezim Forte, which is better,” in turn, is distinguished by great content. Moreover, the composition of “Pancreatin” includes 3850 IU, 275-500 IU and 4620 IU, respectively.

Difference between drugs

If you compare these two drugs in terms of composition, side effects and contraindications, they may appear exactly the same. The main active ingredient in both cases is pancreatin. The effect of both drugs during pregnancy and lactation has not been studied, so it is recommended not to take it or take it with caution.

Are there differences between Mezim and Pancreatin? Let's try to figure out how they differ.

Manufacturer and price

“Pancreatin” is produced by domestic manufacturers and its price ranges from ten to two rubles for twenty tablets. Mezim is produced by the German pharmaceutical giant Berlin-Chemie, whose name has long been a guarantor of quality. The price for this drug is already significantly higher and will be about one hundred rubles for twenty tablets.

Shell

"Mezim Forte" is covered with an enteric coating, which helps deliver the contents to the intestines, where the main work of the drug occurs. Uncoated Pancreatin tablets, unfortunately, lose their effectiveness upon contact with gastric juice.

Indicators of minimal enzyme activity

These drugs also differ in the content of amylase and lipase protease. If on the packaging of Mezim you can read the exact number of enzyme units contained in one tablet, then Pancreatin has a range, since not all manufacturers measure the enzyme activity indicator.

This is the main and, perhaps, the most significant difference between these drugs.

Which drug should I choose?

People experiencing problems with the gastrointestinal tract cannot always find time to consult a doctor, and when they see an advertisement, they ask themselves which drug to give preference to - “Pancreatin” or “Mezim”, believing that they are the same thing.

Only a doctor can give you recommendations on the use of the drug that is right for you.

In any case, before starting active use, it is recommended to consult a doctor. Due to the fact that the drug contains different amounts of enzymes, it is necessary to obtain professional advice on what specific amount is needed in a particular case. If you take medications uncontrollably, you may encounter a situation where complications caused by incorrect use will consume much more time and money than a trip to the doctor.

Most often, “Pancreatin” is prescribed in cases of mild digestive upset, while “Mezim”, containing a larger number of enzymes, is prescribed for the treatment of gastrointestinal diseases indicated in the instructions. However, it is important to remember that both of these drugs cannot be a panacea in case of serious or acute diseases; the patient will require complex, professional treatment. You can also find out on our website Creon or Mezim which is better.

In other words, regardless of which drug looks more attractive, for everyone concerned about the health of their gastrointestinal tract, one decision will be correct - first visit a doctor.

Disturbances in the functioning of the digestive system can be temporary or permanent. Treatment is necessary to replenish missing enzymes when their production is reduced. Then medications containing digestive enzymes are prescribed. Patients with stomach problems often cannot decide on the choice of medications.

Many people buy a cheap drug, thinking that analogues of different price categories have no differences. However, it is important to understand that each drug has its own purpose, and despite the similar composition, they are different. When faced with an illness for the first time, many people think about pancreatin or mezim, which will better help get rid of the torment.

Medicines for pancreatitis

What is pancreatitis?

Pancreatitis is inflammation of the pancreas . The disease can occur in acute or chronic form. Acute pancreatitis can develop unexpectedly, lasts a short period of time and can lead to the development of a chronic form of the disease and a number of complications. Over time, healthy tissue is replaced by scar tissue and becomes unable to produce the required amounts of enzymes necessary for normal digestion. Difficulties arise with digesting food, primarily fats. The processes of digestion of proteins and carbohydrates are also disrupted.

Causes of the disease

The causes of chronic inflammation of the pancreas may be gallstone disease, inflammation of the duodenum, peptic ulcer, injury, alcohol abuse, smoking, unsystematic, irregular nutrition, excessive consumption of spicy and fatty foods. And the simultaneous intake of fatty foods and alcohol can provoke an exacerbation of chronic pancreatitis.

Diseases of the gallbladder and biliary tract also play an important role in the development of pancreatitis.

An overdose of a number of drugs (antibiotics, immunosuppressants, glucocorticosteroid hormones, etc.) can also cause damage to the pancreas.

How does chronic pancreatitis manifest?

First of all, with chronic pancreatitis, a person is bothered by pain. It appears after some time (

30–40 minutes) after eating a large, fatty, fried or spicy meal, is constant or paroxysmal in nature. It is usually felt in the upper abdomen, in the left hypochondrium and can become encircling in nature.

In addition to pain, nausea, vomiting, general weakness, loss of appetite, and thirst may be bothersome. Vomiting during exacerbation of pancreatitis can be frequent, debilitating, and not bringing relief. With a long course of the disease, functional pancreatic insufficiency develops, which is expressed in loose stools, bloating, and weight loss. Weight loss, even with a normal appetite, occurs because the pancreas does not produce enough enzymes to break down food and nutrients are not absorbed. The stool becomes bulky, has a “greasy” appearance, and a fetid, putrid odor appears. The doctor takes into account all the data from clinical and laboratory studies and tests before making a diagnosis.

Description of the drug

These medications are used for the same indications. The drugs should not be used without a doctor's recommendation. It is necessary to undergo an examination and undergo a series of tests. Both drugs help against inflammation and relieve pain.

Surveys of people have shown that the described remedies rarely cause side effects. Many medications are tolerated favorably, and the treatment does not have a negative impact on the body. There are no allergies after them. The drugs provide quick relief and help during attacks of pancreatitis.

They contain the water-soluble enzyme lipase, which is essential for the body. In pancreatitis, lipase appears under the influence of bile and pancreatic fluid. Thanks to them, lipase production is normalized. The content of protease enhances the rheological properties of the blood and improves the functioning of organs. Mezim and Pancreatin help break the peptide bond, normalize repair processes, and break down proteins. The enzymes contained in their composition are needed to improve the process of hematopoiesis, regulate the restoration of damaged cells, break down fibrin and prevent the formation of blood clots.

You should not choose pancreatin or mezim on your own. The appointment is made only by the doctor. To compare both drugs, let's look at them separately.

Mezim

Mezim forte is an enzyme preparation. The main component of mezim is pancreatin, which is responsible for the therapeutic effects. It promotes the breakdown of fat, protein and starch. The performance of the small intestine is normalized, and Mezim also helps with heartburn. Thanks to enzymes, the load on the pancreas is reduced. It takes effect within half an hour.

If you have allergic reactions to the components included in the composition, then you should not take it. Like all medicines, mezim also has side effects. It can cause nausea, stool changes, and an allergic reaction. An overdose of the drug causes a number of complications. With long-term use of mezim, the absorption of iron deteriorates, so if a course of more than 14 days is needed, the doctor prescribes medications containing iron.

Pancreatin

In Pancreatin, the main active ingredient is pig pancreatic fluid, as well as enzymes - protease, amylase, lipase. The tablets are coated, which protects the enzymes from the effects of stomach acid.

Pancreatin is recommended for people with the chronic stage of pancreatitis, gastritis, flatulence, digestive system disorders and enzyme deficiency. It is not recommended to take it if you are intolerant to animal ingredients, during pregnancy, or with acute pancreatitis. Difficulties in prescribing medications often occur due to unclear dosage of the components contained in the composition. Pancreatin is harmless to the gallbladder, available without a prescription, and is not expensive.

Features of the use of drugs

Mezim belongs to a new generation that has a long-term therapeutic effect and has a minimum of adverse reactions . It can be given to children from three years of age.

Pancreatin is considered one of the “old” proven therapeutic agents. Unlike Mezim, it has a number of side effects, but has the advantage of a low price. The drug is used in pediatrics, but it can be given to children starting from the age of six. Previously, the use of the drug is not recommended.

Long-term use of enzyme medications can cause:

• allergies;
• epigastric pain;
• stool disorder;
• dyspeptic disorders.

In children, increased doses of drugs cause constipation.

Joint reception

You cannot take Mezim at the same time as Pancreatin . If during treatment the patient is dissatisfied with the therapeutic effect of taking the medicine, then you cannot independently increase the dosage or use both drugs together. Taking Pancreatin together with Mezim, the patient increases the risk of side effects. In addition, artificially regulated enzyme deficiency with the help of medications in high doses leads to the body’s refusal to independently produce the active substances necessary for the digestion process.

Contraindications to the use of drugs

Mezim and Pancreatin have the following contraindications for use:

• exacerbation of chronic gastrointestinal pathologies;
• acute pancreatitis;
• intestinal obstruction;
• renal coma;
• intolerance to drug components.

Taking medications during pregnancy

There are no laboratory data confirming the safety of the use of drugs of this pharmacological group by pregnant women, as well as young mothers during breastfeeding. If such treatment is required, it should not be used without first consulting a doctor.

Before or after meals

Take Mezim or Pancreatin tablets before meals with a large volume of water. In this case, doctors recommend drinking enzymes with medicinal alkaline water like Essentuki. The tablets can also be taken with food, but the medicine must not be chewed. When the drug reacts with saliva or stomach contents, the therapeutic effect of the drug is partially or completely neutralized.

What is the difference between them and which is better?

Mezim is a relatively new drug on the pharmacological market compared to Pancreatin. They are considered analogues of each other. Both drugs are intended to improve the digestive system and eliminate heaviness in the stomach, but it is important to know how one drug differs from the other.

The difference between Mezim and Pancreatin is that Pancreatin is produced in Russia, and Mezim is produced abroad, they differ in the size of active enzymes. Mezim contains a certain amount of all components, but Pancreatin contains undefined doses. In terms of enzyme content, they are the same.

To the question of which is better - mezim or pancreatin, the answer will be controversial, since they have different purposes. Pancreatin is prescribed for mild disorders of the digestive system, since it contains a low content of digestive enzymes. Mezim is considered more active, therefore it is prescribed for the treatment of the gastrointestinal tract. If the patient is tolerant to only one of the drugs, replacing it with an analogue is prohibited.

Can pregnant women take Pancreatin or Mezim?

There is no direct ban on the use of these drugs during pregnancy. In laboratory experiments, neither drug had a negative effect on the fetus.

However, given the lack of a sufficient number of clinical studies on this category of patients, pregnant women can take them only as prescribed by a doctor. Pancreatin-based products are recommended to be used only if the likely benefit to the mother outweighs the risk of complications from the fetus.

Typically, pregnant women are first prescribed a small dose of the medication and their tolerability is monitored. If no problems arise, then the dosage is gradually increased to the recommended one.

Pancreatin or Creon - which is better for the pancreas

Manufacturer: Abbott, Germany

Release form: capsules

Active ingredient: pancreatin

Creon 10000 and 25000 are several times more effective than Pancreatin for a number of reasons:

• this is an original drug with an evidence base;
• capsules contain minimicrospheres that are resistant to gastric juice due to the shell;
• safety and possibility of use by children of the first year of life and pregnant women;
• the therapeutic effect begins 15 minutes after entering the intestines;
• convenient storage in a jar, no need to put it in the refrigerator to preserve its properties;
• positive reviews from doctors and patients.

The cost of Creon is higher.

When choosing between Creon or Pancreatin for one-time use, you can choose the second drug. It is up to 6 times cheaper than its analogue.

What is the difference between Creon or Pancreatin according to doctors and pharmacists:

1. Release form: the first is in capsules, the second in tablets.
2. The place of action is in the intestines and stomach, respectively.
3. Efficiency - Creon is stronger, since all enzymes reach the intestines and begin to act there; Some of the Pancreatin enzymes are destroyed in the stomach.
4. Storage – Creon does not require special conditions; Pancreatin must be placed in the refrigerator.

What to choose depends on the indications, frequency of use and financial capabilities.

Pancreatin analogues

Pharmacies offer analogues and substitutes of Pancreatin of several groups:

• synonyms – drugs of domestic or imported origin containing pancreatin;
• combination products – along with pancreatin, they contain other medicinal substances;
• analogues from other pharmacological groups, but having the same properties and indications.

Allohol

Manufacturer: Biosynthesis, Pharmstandard, etc., Russia

Release form: tablets

Active ingredient: activated carbon, bile, dry garlic, nettle extract

The cheap analog Allohol is designed for better functioning of the gastrointestinal tract:

• prevents fermentation and decay processes;
• has a choleretic effect;
• helps with atonic constipation.

It is used in courses depending on the patient’s indications and complaints - from 3–4 weeks to 3 months.

Holenzym

Manufacturer: Belmedpreparaty, Belarus or Biosintez, Russia

Release form: tablets

Active ingredient: bile, pancreas powder, small intestinal mucosa powder

The Cholenzym analogue combines several properties: it promotes the formation and secretion of bile, improves digestion, and facilitates the digestion of incoming proteins, fats and carbohydrates. The drug is suitable not only for diseases of the digestive tract, but also to facilitate digestion during a sedentary lifestyle, a change in diet, and overeating. Cholenzym is taken 1-3 times a day depending on the symptoms and severity of the condition.

Enzistal

Manufacturer: Torrent Pharmaceuticals, India

Release form: tablets

Active ingredient: pancreatin, bile components, hemicellulase

An analogue of Pancreatin in tablets is the combined drug Enzistal. Contains additional components, resulting in a wider range of therapeutic effects:

• promotes better digestion of food and breakdown of proteins, fats, carbohydrates;
• relieves or alleviates symptoms associated with digestive disorders - pain after eating in the abdominal area, increased gas formation, flatulence, shortness of breath, heaviness;
• reduces the formation of gases in the intestines;
• increases bile production;
• promotes better absorption of incoming vitamins and minerals.

Also available in pharmacies is the drug Enzistal-P - an analogue containing only pancreatin, without additional components. The advantage is that you don’t need special conditions for storage or refrigeration.

Omeprazole

Manufacturer: Ozone, Kanonpharma, Promed, AVVA RUS, Sintez, Russia or Teva, Hungary

Release form: capsules

Active ingredient: omeprazole

Synonyms: Omez, Gastrozol, Ultop, Losek, Ortanol, etc.

The prescription analogue Omeprazole acts on stomach cells and reduces the production of hydrochloric acid. As a result, heartburn, stomach pain, sour belching and other symptoms of dyspepsia and gastritis are reduced.

Pangrol

Manufacturer: Berlin-Chemie, Germany or Italy

Release form: capsules

Active ingredient: pancreatin

The drug Pangrol is an analogue of Pancreatin in capsules, which is more effective. The capsule contains mini-tablets. Pancreatin analogue 10,000 units enters the stomach, the gelatin shell of the capsule dissolves. The active substance itself begins to act exclusively in the intestines.

You can learn about other substitutes in pharmacy windows, in advertising or from doctor's prescriptions.

• Unienzyme is a drug for better digestion, replenishes enzyme deficiency, eliminates heaviness in the abdomen, diarrhea and other symptoms of intestinal dysfunction.
• Wobenzym is an enzyme preparation that reduces inflammation in the gastrointestinal tract and the entire body, the disadvantage is its high cost.
• Karsil is a medicine for protecting and restoring the liver and eliminating associated symptoms (pain, heaviness, bitterness).
• No-Shpa is an antispasmodic drug for pain and colic.
• Trimedat is an imported analogue that regulates intestinal motility and eliminates problems with stool (diarrhea or constipation), flatulence, bloating, and a feeling of heaviness.
• Motilium - regular and dispersible tablets, the suspension has the same effect as Trimedat, additionally eliminating nausea and vomiting.

Pancreatin and mezim comparison

Snacking on the go, sedentary work, stress, and diet disorders lead to digestive disorders and the development of diseases of the digestive tract. To normalize the condition, medications with active enzymes are suitable, which do not mask discomfort, but help digestion return to normal. Most often, Pancreatin or Mezim are prescribed. These are analogue drugs, but they have differences.

How they affect the body

Due to pancreatin (the active substance), both drugs are able to quickly restore digestion and eliminate the unpleasant symptoms of gastrointestinal diseases. The drugs are suitable for the prevention and treatment of diseases of the gastrointestinal tract, for restoring intestinal function after overeating, poisoning, diet and other changes in the usual routine.

The active substance of the medicine helps the pancreas break down fats, proteins and sugar. As a result, nutrients are absorbed faster and digestion is accelerated. The maximum effect of the drugs is observed half an hour after administration.

Both types of tablets have a protective coating that protects against aggressive gastric juice. Due to this, the active substances enter directly into the intestines.

Indications for use

Medicines are prescribed in the following cases:

• chronic pancreatitis beyond the acute stage;
• recovery after radiation;
• non-infectious diarrhea;
• dyspeptic symptoms;
• operations on the gastrointestinal tract;
• Botkin syndrome;
• preparation for operations and studies of the gastrointestinal tract;
• passive lifestyle;
• slow digestion;
• liver diseases;
• gastritis;
• duodenitis;
• colitis;
• gastroduodenitis;
• cholecystitis;
• other diseases of the stomach and intestines;
• weak pancreas function;
• increased gas formation;
• cystic fibrosis.

Due to its lower enzymatic activity, Pancreatin can be taken for any type of gastritis and chronic pancreatitis. This remedy is best used after overeating or eating fatty foods. Mezim has a stronger effect, so it is not recommended to take it for mild digestive abnormalities.

Is there a difference between medications

Medicines are analogues of each other. They contain the same active ingredient, they have similar indications and contraindications for use. But there are also differences. The main difference is the enzyme activity indicator. But the side effects and characteristics of administration also differ in different categories of patients.

Indicators of minimal enzyme activity

Both drugs are enzyme preparations. They contain lipases, proteases, and amylases. In Mezim, the amount of each enzyme is calculated; in Pancreatin, only the general range is indicated. Conventionally speaking, one Mezim tablet corresponds to approximately three Pancreatin tablets in terms of enzyme activity.

Pancreatin has a milder effect than Mezim. This difference is taken into account when choosing treatment depending on the characteristics and severity of the disease.

Which is better Pancreatin or Mezim

The drugs have three differences: price, country of origin and enzyme activity. The last difference is the most important. It is it that decides what is best in a particular case.

For mild indigestion or overeating, Pancreatin is suitable, for the treatment of severe diseases - Mezim. This medicine is more suitable for systematic use. If you need one-time help, then you should choose Pancreatin.

But it is better to consult a doctor before starting use.

Drug compatibility

It is not recommended to use both products at the same time. These are analogue medications; taking them together can cause an overdose.

Directions for use and dosage

Pancreatin should be taken after meals or during meals. The average dosage is one to three tablets three times a day. The general course of treatment depends on the disease.

Mezim should be taken before meals. The average dosage is one to two tablets three times a day. The dosage can be increased to 4 tablets at a time. The total duration of therapy is selected individually.

When treating children, the course of treatment is determined by the doctor. The dosage is calculated based on the child's weight.

In both cases, the overall course of treatment can last from one day to several years.

special instructions

Medications reduce iron levels, so it is recommended to combine medications with nutritional supplements. If treatment lasts less than 14 days, then iron supplementation is not required. When treating severe gastrointestinal diseases, it is useful to adhere to a gentle diet.

Before starting treatment, it is recommended to read the instructions for use included in the package with the medicine.

Pregnancy and lactation

It is not recommended to take medications during pregnancy and breastfeeding. But if the benefit to the mother outweighs the risk to the baby, then the doctor may allow it.

Childhood

Both drugs can be used by children from three years of age (the tablet cannot be divided into several doses). If the child can swallow a whole tablet, then administration at an earlier age is allowed. The dosage is calculated by the doctor individually, based on body weight.

Elderly age

Admission allowed. In older people, pancreatic secretion decreases, so larger doses of drugs may be needed. Treatment can only take place under the supervision of a doctor.

Side effects of Pancreatin and Mezim

Side effects include nausea, stool upset, and allergies.

Contraindications to the use of Pancreatin and Mezim

For what diseases and conditions is it prohibited to take medications:

• acute pancreatitis and exacerbation of the chronic form of the disease;
• allergy to the composition.

Interaction with other drugs

Both drugs reduce iron levels and reduce the effect of sugar-containing drugs. Antacids reduce the effect of medications.

Interactions with other medications are not exactly known. It is recommended to tell your doctor about all medications you are taking.

Alcohol compatibility

It is not recommended to combine medications with alcohol. The latter reduces the effect of drugs. This combination also has a bad effect on the pancreas.

Overdose

In case of overdose, side effects increase, constipation or diarrhea is observed. For treatment, you need to stop taking the drug.

Conditions for dispensing from pharmacies

Both drugs are available without a prescription.

Storage conditions

Keep away from children, moisture and sunlight at temperatures up to 25 °C.

Best before date

Both medications are stored for three years.

Analogs

Medicines are analogues of each other, but there are other substitutes: Creon, Pancreazim, Panzinorm, Mezim forte, Penzital.

Source: https://mybabic.com/info/pankreatin-i-mezim-sravnenie/

Pharmacological action of Pancreatin

The enzyme preparation Pancreatin contains porcine pancreatic juice, protease, lipase and amylase. The outside of the tablets is coated, protecting it from the aggressive effects of the acidic environment of the stomach.

Pancreatin is indicated for adults and children with chronic pancreatitis, gastritis, indigestion, and lack of enzymes. Since most of the ingredients are of animal origin, the medication is prohibited for use if they are intolerant. Sometimes doctors do not prescribe Pancreatin tablets for acute inflammatory processes in the pancreas, exacerbation of chronic diseases, or pregnancies of various stages.

The enzyme agent is almost always well tolerated by the body, but the occurrence of undesirable reactions of the body, for example, attacks of vomiting and nausea, cannot be ruled out.

The instructions for use of the tablets do not indicate the exact amount:

For this reason, it can be difficult to dose the drug adequately. The price per package of the product varies between 15-75 rubles, depending on the number of tablets in it. As reviews show, this is the product that is purchased most often.

The medicine should be taken with food or on an empty stomach, washed down with a sufficient amount of still water. Pancreatin is often recommended for mild digestive disorders because pancreatin levels are low. The doctor prescribes taking 1-5 tablets, the dosage is calculated depending on the patient’s weight.

Definition

Pancreatin refers to digestive enzyme agents, which are an extract of the contents of the pancreas. It contains pancreatic enzymes protease, lipase, amylase, which are involved in the digestion of fats, proteins and carbohydrates. Pancreatin is used for diseases of the gastrointestinal tract or for errors in nutrition; it allows you to compensate for the insufficient activity of the body's own enzymes, and in addition, significantly improves the digestion process. Pancreatin is produced under various trade names, including Mezim.

Pancreatin

Mezim is a digestive enzyme remedy that replenishes the deficiency of pancreatic enzymes in the body. In addition, it has amylolytic, proteolytic and lipolytic effects. The drug contains pancreatic enzymes such as trypsin, chymotrypsin, lipase and alpha-amylase. The drug is responsible for improving the functional state of the gastrointestinal tract, and also normalizes digestion processes. Mezim-Forte is one of the most popular drugs intended for the treatment of the gastrointestinal tract. This is one of the many analogues of Pancreatin; it belongs to the category of digestive enzymes.

Mezim