Drotaverine for bloating: instructions for use

Composition and release form

Drotaverine is available in two forms:

1. ampoules (injection solutions);
2. pills.

The active ingredient is drotaverine hydrochloride. Each of the forms is absolutely identical in the amount of active ingredient - 40 mg contains one tablet and ampoule.

Drotaverine is produced by many pharmaceutical companies, the purpose and use of which do not affect the quality of the drug itself, they simply indicate a difference in the company of release.

That’s why Drotaverine has many names:

• Drotaverine - Teva;
• Drotaverine - Ellara;
• Drotaverine – Forte;
• Drotaverine – FPO;
• Drotaverine;
• Vero - Drotaverine.

Photo:

When buying Drotaverine from Darnitsa or any other, you should not worry about the quality of the product, since in all companies it is selected and has the same qualities, so domestic or even foreign packaging will contain the same drug, which does not differ from each other.

Use during pregnancy and lactation

Drotaverine hydrochloride, the active substance, is able to penetrate the hematoplacental barrier. In other words, this component of the drug can have a direct effect on the fetus and in one way or another influence its development. A specialist may prescribe medication if the hypothetical benefit for the pregnant woman is higher than the potential threat to the child.

During breastfeeding, you should avoid taking Drotaverine, since it passes into mother's milk and, accordingly, is passed on to the baby. If refusal is impossible, then you need to think about temporarily stopping breastfeeding and transferring the child to artificial formula.

Often, medicine can be prescribed during premature birth, to relieve the tone of the uterus (this will stabilize the condition if there is a threat of miscarriage and will help promptly and without harm to the mother’s health to begin all the necessary auxiliary actions), as well as in the period after childbirth to stop contractions.

Whether Drotaverine can be prescribed to children is an open question. Some pediatricians and therapists are against therapy using this medicine and strongly recommend using it only after reaching 12 years of age, while others believe that the drug will not cause harm and prescribe it from 5-6 years of age. In any case, the treatment process with this medicine should be under the constant supervision of the attending physician.

Indications for use

Drotaverine is a drug that is an antispasmodic, due to which it helps with pain in the head, abdomen, stomach, intestines, it also dilates blood vessels and allows blood pressure to decrease, and therefore is an excellent antihypertensive agent.

Therefore, Drotaverine can be prescribed to an adult or child with the following symptoms and diseases:

• Severe pain during menstruation.
• Pain in the abdomen (stomach, intestines, uterus) caused by spasm of smooth muscles.
• Diseases of the urinary system (cystitis, urolithiasis, pyelitis, etc.).
• Diseases of the liver and gall bladder (hepatic colic, cholangitis, cholecystitis, papillitis and much more).
• The need to relax smooth muscles in women - with increased uterine tone before childbirth, which begins prematurely, in order to prevent miscarriage and premature birth of a child.
• Spasms of blood vessels to relieve headaches.
• Diseases of the digestive tract (gastritis, stomach ulcers, irritable bowel syndrome, spastic colitis and constipation, enteritis, proctitis, etc.).
• Hypertension to lower blood pressure.

DROTAVERIN

– drotaverine hydrochloride (drotaverine)

Release form, composition and packaging

◊ Pills

yellow with a greenish tint, flat-cylindrical, chamfered.

Excipients: lactose monohydrate 70 mg, potato starch 21.6 mg, povidone K-30 4.2 mg, crospovidone 1.4 mg, talc 1.4 mg, magnesium stearate 1.4 mg.

10 pieces. – contour cellular packaging (aluminum/PVC) (1) – cardboard packs. 10 pcs. – contour cellular packaging (aluminum/PVC) (2) – cardboard packs. 10 pcs. – contour cellular packaging (aluminum/PVC) (5) – cardboard packs. 10 pcs.

– contour cellular packaging (aluminum/PVC) (20) – cardboard packs. 10 pcs. – contour cellular packaging (PVC/boom) (1) – cardboard packs. 10 pcs. – cellular contour packaging (PVC/boom) (2) – cardboard packs. 10 pcs. – cellular contour packaging (PVC/boom) (5) – cardboard packs.

10 pieces.

– cellular contour packaging (PVC/boom) (20) – cardboard packs.

Pharmacokinetics

When taken orally, absorption is high, half-absorption period is 12 minutes. Bioavailability – 100%. It is evenly distributed throughout the tissues and penetrates smooth muscle cells. Cmax in blood plasma – 2 hours. Communication with plasma proteins – 95-98%. It is mainly excreted by the kidneys, and to a lesser extent – ​​with bile. Does not penetrate the blood-brain barrier.

Indications

Spasm of smooth muscles in diseases of the biliary tract:

cholecystolithiasis, cholangiolithiasis, cholecystitis, pericholecystitis, cholangitis, inflammation of the duodenal papilla.

Smooth muscle spasm in urinary tract diseases:

nephrourolithiasis, urethrolithiasis, pyelitis, cystitis, bladder spasm.

As an auxiliary therapy: for spasms of smooth muscles of the gastrointestinal tract: peptic ulcer of the stomach and duodenum, gastritis, spasm of the cardia and pylorus, enteritis, colitis, spastic colitis with constipation and irritable bowel syndrome with flatulence; tensor headache; algodismenorrhea, threatened miscarriage, threatened premature birth; spasm of the uterine pharynx during childbirth, prolonged opening of the pharynx, postpartum contractions.

When conducting some instrumental studies, incl. cholecystography.

Dosage

For adults

, orally 40-80 mg (1-2 tablets) 2-3 times a day.

For children

, orally at the age of 3-6 years – 40-120 mg in 2-3 doses, maximum daily dose – 120 mg; 6-18 years – 80-200 mg in 2-5 doses, maximum daily dose – 240 mg.

Dizziness, headache, insomnia, palpitations, tachycardia, feeling of heat, increased sweating, nausea, constipation, decreased blood pressure, allergic skin reactions, angioedema, urticaria, rash, itching.

Drug interactions

When used concomitantly, drotaverine may weaken the antiparkinsonian effect of levodopa. Enhances the effect of papaverine, bendazole and other antispasmodics (including m-anticholinergics), the decrease in blood pressure caused by tricyclic antidepressants, quinidine and procainamide.

Phenobarbital increases the severity of the antispasmodic effect of drotaverine. Reduces the spasmogenic activity of morphine.

Pregnancy and lactation

Controlled studies have not been conducted in pregnant women, but the potential benefit may justify the use of drotaverine for the mother, despite the possible risk to the fetus. Contraindicated during breastfeeding.

Use in childhood

Contraindicated in children under 3 years of age.

For impaired renal function

Contraindicated in cases of severe renal failure.

For liver dysfunction

Contraindicated in cases of severe liver failure.

Conditions for dispensing from pharmacies

The drug is approved for use as a means of OTC.

Storage conditions and periods

Store the drug in a dry place, protected from light, at a temperature not exceeding 25°C. Keep out of the reach of children.

Shelf life – 3 years. Do not use after the expiration date stated on the packaging.

The description of the drug DROTAVERINE is based on officially approved instructions for use and approved by the manufacturer.

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Source: https://health.mail.ru/drug/drotaverin_1/

Mode of application

The drug Drotaverit can be taken in tablets and ampoules.
It is important how to take the medicine - before or after meals. The tablets are taken immediately after meals, even after a small snack you can take the medicine. These tablets should not be chewed, only swallowed with water. It doesn’t matter how you take the injections in relation to food. Ampoules can be administered intramuscularly, intravenously, subcutaneously and intraarterially. For intravenous and intra-arterial administration, Drotaverine should be diluted with 20 mg of physiological solution; for other injections, a regular solution of Drotaverine is suitable. The injections must be given by a specialist.

Drotaverine can be taken by adults (even pregnant women) in the following dosage:

1. Tablets - one or two tablets are taken no more than 3 times per day. An adult can be given no more than 240 mg per day, which corresponds to six tablets.
2. Injections - one or two ampoules 1-3 times during one day, but the daily dose should not exceed six ampoules.

For children, the dosage of the drug is different and depends on the age of the child:

Pills:

1. from 3 years to 6 years – a quarter or half of a Drotaverine tablet is prescribed 2-3 times a day. The daily dose is no more than three tablets.
2. from 6 to 12 years - half or a whole tablet is prescribed to be taken 2 to 5 times a day. The daily dose of the drug should not be more than 5 tablets.

Injections:

1. from 3 years to 6 years – 10-20 mg of Drotaverine 1-3 times a day, but not more than 120 mg of the drug per day.
2. from 6 to 12 years – 20 mg 1-3 times a day, but not more than 200 mg per day.

How much medication can be given to a child in a particular case must be decided by the doctor; the same applies to taking the drug by adults.

It is better not to exceed the specified dosage to avoid side effects and harm to the body.

Drotaverine - what are these tablets for, who should take them and how?

Quite often, patients ask doctors the question of what Drotaverine helps with and in what specific cases it is indicated.

This synthetic medicine is intended to relieve pain resulting from a malfunction of internal organs.

The drug has an antispasmodic and vasodilating effect, reduces excessive activity of intestinal contractions, and reduces blood pressure.

It is widely used for the following diseases:

• cholecystitis;
• liver spasm;
• biliary dyskinesia;
• urolithiasis disease;
• gastroduodenitis;
• cystitis;
• pyelitis;
• gastritis and others.

What does Drotaverine tablets help with?

What Drotaverine is, what these tablets are for - this issue needs to be carefully understood before stocking up on the medicine.

The medication has an antispasmodic, vasodilator, myotropic, hypotensive effect.

Regardless of what drug Drotaverine is taken, it reduces the amount of active ionized calcium, which enters smooth muscle cells and is quickly absorbed in the gastrointestinal tract.

The great advantage of the drug is that Drotaverine, no matter what you take these tablets for, does not affect the autonomic and central nervous systems. That is, taking the drug does not disrupt the normal rhythm of life and does not dull reactions. In this case, the pills begin to act within about 12 minutes, after they enter the body and dissolve there.

Drotaverine for pain

This is the first answer that comes to mind: Drotaverine - what are these tablets for? From pain.

The miraculous antispasmodic mechanism is directly related to the ability of the drug to change the potentials of cell membranes and their permeability.

The same effect can be achieved with spasms of different origins - both nervous and muscle. You can take Drotaverine for headaches of any nature and expect a positive result.

Drotaverine on temperature

For many, this drug is purely an anesthetic, but in fact, Drotaverine hydrochloride can also be used instead of an antipyretic. Moreover, the medicine works no worse than the main remedies for fever. The secret is that the medicine has a vasodilating effect. Thanks to this, the temperature quickly “leaves” from the body, evaporates, to put it simply.

Drotaverine for blood pressure

The vasodilating effect makes it possible to use the drug Drotaverine during pressure surges. When the vessels narrow, the tissues and organs that feed through them begin to starve - they do not receive as much oxygen as they need. Drotaverine helps restore normal blood circulation and thereby put the whole body in order.

Drotaverine for cough

This is one of the most unexpected, but no less effective uses of the product.

When remembering the medicine Drotaverine, what these tablets help with, cough is the last thing that comes to mind, but the drug actually helps with this problem. When spasms are painful and interfere with sleep.

To get rid of them, you need the drug Drotaverine in the amount of two pills and one tablet of Suprastin. This composition will clear up your cough in a matter of minutes and restore restful sleep.

Drotaverine for nausea

Some people who are keen on self-medication are sure that one of the problems for which Drotaverine is prescribed is nausea, and this issue needs to be clarified.

The fact is that it is dangerous to take any painkillers and Drotaverine, including for nausea and other gastrointestinal disorders. The reason is that poisoning is always accompanied by excessive gas formation.

Antispasmodics relax smooth muscles, thereby making it even more difficult for gases to escape. That is, they not only do not help, but even worsen the condition and well-being.

Side effects

The drug can cause a number of side effects on the human body in certain cases:

• dizziness;
• nausea;
• insomnia;
• feeling of heat;
• sweating;
• increased heart rate;
• decreased blood pressure;
• collapse;
• anaphylactic shock.

Overdose

In case of an overdose of the drug, paralysis of the respiratory center and cardiac arrest are possible. It is necessary to immediately stop taking the drug, drink sorbents and begin symptomatic therapy to maintain vital functions.

Drotaverine and No-shpa: what is the difference?

Drotaverine and No-shpa are considered analogues not only in composition, but also in their mode of action on the body. Their differences are shown in the table.

No-spa as a substitute for Drotaverine is quite suitable in its qualities and is sometimes even more effective. But this is only for certain people, and Drotaverine has even more advantages both in price and in the possibility of use.

Drotaverine

Drotaverine is a drug that is widely used as an antispasmodic for various pathologies.

The instructions for use, which are provided in this article, contain important recommendations for patients and doctors that allow rational use of the medicine.

The information is supplemented by prices, reviews from patients and specialists, as well as lists of Drotaverine analogue substitutes in Russia, which can be used to replace the medicine.

Compound

Drotaverine hydrochloride (international name - Drotaverini in Latin) is the only active ingredient of the drug. The amount of this ingredient in one dose differs in different forms:

• ampoules - 20 mg of Drotaverine in 1 ml of solution;
• tablets - 40 or 80 mg.

Other components in solutions: sterile water, Sodium metabisulfite.

Other components in tablets: Si oxides, lactose, starches, cellulose in various forms, Ca stearates, PEG, Ca carbonates, yellow dye.

Release form

The drug is produced by different manufacturers in the following forms:

1. Solutions for injection are yellowish-green liquid. One ampoule contains 2 ml of the prepared solution. The original packaging contains 10 ampoules and instructions for use.
2. Tablets for oral use, round in shape and colored yellow. Packages contain 20 or 50 tablets and official instructions for the drug.

pharmachologic effect

Pharmacological group - antispasmodics, drugs that are used to treat diseases of the gastrointestinal tract.

The mechanism of action is based on inhibition of phosphodiesterase and myosin production, causing spasms in smooth muscles.

Pharmacological actions (properties) of Drotaverine:

• elimination of spasms in smooth muscle fibers;
• stimulation of blood flow in tissues;
• analgesic effect;
• vasodilation. This effect leads to the fact that Drotaverine reduces high blood pressure. This feature should be taken into account when prescribing the drug, especially to patients with hypotension.

Considering the mechanisms of action of the drug, Drotaverine is less effective against headaches and toothaches.

Metabolism of Drotaverine occurs in the liver.

With alcohol

There are no descriptions of negative consequences that develop when the drug interacts with alcohol. To reduce the negative impact on the functioning of the liver and kidneys, it is recommended to exclude the combination of Drotaverine and alcohol due to unknown consequences of compatibility.

Terms of sale and storage

The drug in tablets is dispensed from pharmacies without prescriptions in Latin. The drug in solution is subject to prescription (indicate the INN of the drug).

Important! Self-medication with Drotaverine is not recommended.

Storage of the medicine does not require specific conditions. The optimal temperature should not exceed 25⁰C. It is recommended to store the drug in dry places away from children.

Analogs

Analogs of this drug include Papaverine, No-shpu, Bioshpu, Spasmonel, Spasmol, Spakovin, Nikoverin, Platifilin, Papazol.

Price

In Ukraine and Russia, the cost of the drug largely depends on the pharmacy and the manufacturer. The approximate price of the drug can be seen in the table for the largest cities of these countries.

Reviews

Camilla, Kyiv The stomach always hurts very much in the first days of menstruation. I used to take Ibuprofen or Spazmalgon, but then they stopped helping. I tried Drotaverine. It relieves pain well, not for long, but the main thing is to get through the first day. They will drink it for now, but maybe the body will get used to it.

Valeria, Kremenchug As long as I can remember, my mother gave these pills for headaches and then for abdominal pain (when she got older). The pills have always helped well, and they still work well. I sometimes drink a couple of times a month if necessary, and everything goes away quickly.

Nikolai, Vinnitsa I often have a headache (noisy work). I take pills sometimes, and they help quickly. The main thing, I think, is not to be overzealous, suddenly I’ll get used to it, and then they won’t help, but so far everything is good. I take one tablet during the day, and the pain quickly goes away and does not return.