Creon or Hermital, which is better - We treat the liver

Creon and Hermital - what's the difference?

The drugs Ermital and Creon belong to the pharmaceutical group of digestive products. The active ingredient pancreatin, which is part of their composition, is an enzymatic complex extracted from a natural source (pork pancreas). Pancreatin contains lipase, amylase and proteases.

It is believed that the Creon brand is the most used in Europe for enzyme replacement therapy. It is produced by Abbott Laboratories (Germany). Ermital is also produced by the German company Nordmark Arzneimittel.

"Ermital 10000" - 50 capsules

For drugs of this kind, the important issue is the delivery of digestive enzymes to the exact place where they are secreted in the body. To achieve this, methods are being developed to protect them from the damaging effects of gastric juice. That is why the release form of Creon is quite complex. It represents:

• pancreatin minimicrospheres,
• with an acid-resistant shell,
• placed in a gelatin capsule.

The Ermital release form is similar. It is available in the form of microtablets coated with a film coating that is resistant to the action of gastric juice. Microtablets are contained in a common gelatin capsule.

What is the difference between Creon and Hermital in dosage? Rationing of drugs of this type is carried out not on the dry weight of the substance, but on the activity of lipase (a unique pancreatic enzyme) and is expressed in units of activity.

Creon on our pharmacological market is represented by the brands Creon 10000 and Creon 25000 with the corresponding dosages of lipase:

1. 10,000 units,
2. 25,000 units

There are three drugs in the Ermital brand line:

1. 10,000 units,
2. 25,000 units,
3. 36,000 U of lipase.

There are differences between Ermital and Creon in the activities of other enzymes.

Such a variety of enzymatic activity profiles allows you to approach the choice of “Hermital or Creon - which is better” individually, selecting the most suitable combination of amylase/protease/lipase in accordance with your own well-being.

What to choose: Hermital or Creon

Enzyme preparations obtained from pig pancreatic juice extract have been used in the treatment of digestive diseases for a long time. But not all of them are considered effective, since most drugs are destroyed under the influence of gastric juice. But there are modern drugs - Ermital or Creon.

Ermital and Creon are enzyme preparations obtained from an extract of pig pancreatic juice and are included in the composition.

Differences in composition and dosage form

Creon is an enzyme preparation widely used in gastroenterology. It is produced in the form of gelatin capsules, inside of which there are minimicrospheres or granules coated with an enteric coating that is resistant to the acidic environment of the stomach.

The active substance pancreatin, isolated from pancreatic tissue (PG) of pigs, includes pancreatic enzymes (lipase, amylase, protease) necessary for the digestion of fats, carbohydrates and proteins. Creon is available in three dosages: 10,000, 25,000 and 40,000 units (U).

Creon 10,000 contains 150 mg of pancreatin in one capsule with enzyme activity:

• lipase – 10,000 units;
• amylase – 8,000 units;
• protease – 600 units.

The cost of a drug with a dosage of lipase 10,000 varies from 280 to 320 rubles per package of 20 capsules.

Dosage form of Creon

The analogues presented on the pharmaceutical market, which can replace Creon if necessary, differ from the original.

The difference in drugs is due to the following characteristics:

• dosage form;
• dosage;
• enzyme activity;
• the presence in the composition, in addition to pancreatin, of other active ingredients;
• company manufacturer;
• price.

Table: release forms, packaging, dosage and prices of analogues:

Preparations in the form of gelatin capsules with microtablets or microgranules inside are considered better.

Unlike enteric-coated tablets, if the capsule enters the gastrointestinal tract:

• The shell dissolves in the stomach.
• Microgranules (minimicrospheres) are released and thoroughly mixed with the contents of the stomach.
• The granules enter the small intestine along with the bolus of food, where their shell is destroyed.
• The released enzymes are evenly distributed in the contents of the small intestine.
• Under the influence of substances, proteins, fats and carbohydrates are broken down.

Why are lipase, amylase and protease needed?

Lipase breaks down neutral fats. It is produced only in the pancreas. It is estimated that the average adult requires about 200,000 units of lipase per day to avoid symptoms of steatorrhea (poor absorption of fats and their elimination in the feces).

Amylase “deals” with starch, gradually breaking it down into dextrins and maltose, from which glucose is then obtained. This substance is secreted by both the pancreas and salivary glands.

Proteases are needed to digest proteins. There are several types of them, they are produced not only in the pancreas, but also in the stomach, so deficiency of amylase and proteases is not as critical as the absence of lipase.

When and how are enzymes prescribed?

Enzyme replacement therapy is needed when postprandial (after eating) pancreatic enzyme secretion falls below 10% of normal levels. Due to impaired absorption of nutrients, the following is observed:

• weight loss,
• flatulence, diarrhea,
• steatorrhea,
• anemia,
• hypovitaminosis.

Enzyme preparations should be prescribed by a doctor after examination and conclusion on the advisability of enzyme therapy. Mandatory practice is to select the dose of medication in accordance with the severity of enzyme deficiency and the composition of the diet.

For adult patients, the recommended dose is 50,000–75,000 U of lipase per main meal and 25,000 U for a snack. Patients are instructed that the dose can be increased according to the consumption of fatty foods, but dietary requirements must still be followed. Symptoms of steatorrhea and weight loss indicate an insufficient dose of the enzyme and the need to adjust it.

Uncontrolled use of enzyme medications can have a detrimental effect not only on the condition of your intestines, but also on your overall health, so let your doctor decide: Creon or Hermital, what to choose and in what dose to take.

How effective are enzyme products?

Over the many years of clinical use of Creon, more than 20 placebo-controlled randomized studies have been conducted. A retrospective analysis showed that in various forms of exocrine pancreatic insufficiency (chronic pancreatitis, gland resection, cystic fibrosis), the use of Creon reduced steatorrhea in patients by 25–30% compared with the placebo group.

The rate of protein absorption in patients taking the drug for several months was 97%, while in the placebo group it was only 24%.

At the same time, side effects in the form of gastrointestinal symptoms were observed in the group taking Creon no more often than in the placebo group. Interestingly, when patients were prescribed drugs to reduce acidity (proton pump inhibitors, histamine H2 receptor blockers) in combination with enzymes, the incidence of complications increased.

Cost of courses for adults and children

If we compare Creon and Ermital, the price of drugs with the same activity differs by almost 2 times. The price of Creon 25,000 (20 capsules) ranges from 600 to 650 rubles. Ermital of the same activity and in the same quantity costs from 340 to 380 rubles.

If the recommended intake for an adult is 2 capsules per meal, then at least 6 capsules will be required per day. A package of 20 capsules will not last long. It is more profitable to buy a pack of Ermital (25,000 units), which contains 50 capsules. Its price is approximately equal to a package of Creon 25000, which contains only 20 pieces.

Enzyme agents with an activity of 10,000 units are usually used in pediatric practice. For children 3-4 years old (weighing up to 20 kg), half a capsule is required, and for 3 doses – 1.5 capsules. Then a package of medicine for 20 capsules will last for almost 2 weeks. The price of such a package of Ermital is about 200 rubles, Creon costs 40% more.

Which product to choose

There is no consensus on which drug is better. First of all, the choice depends on the individual characteristics of the patient’s body, the tolerance of the main and auxiliary substances, as well as financial capabilities.

If we take the price of enzyme preparations for comparison, Ermital is more affordable for the same number of capsules per package. At the same time, it cannot be said that the drugs are in the high price range. The average price of the drug "Creon" varies from 270 to 700 rubles, depending on the dosage of the active substance. Ermital, depending on the dosage, will cost from 160 to 350 rubles.

The composition of the medicinal products is close in basic characteristics to human pancreatic secretion; it contains a number of enzymes necessary for normal functioning, which allows stabilizing the functioning of the digestive system.

Before making a choice in favor of a particular medication, it is necessary to undergo a thorough examination and identify possible risk areas. With the competent participation of a doctor, the funds will be spent on the medicine that will bring the greatest health benefits.

Ermital and Creon are equally effective in restoring the balance of enzymes in the body. The best remedy for each person is different; there is no single template in matters of health.

Resection of the pancreas or chronic diseases of the organ impair the secretion of pancreatic juice. Fats, carbohydrates and proteins supplied with food cease to be absorbed. Creon or Ermital are drugs in which the composition of enzymes is close to the natural secretion of the pancreas. By taking them, you don't have to worry about indigestion. Let's look at the main characteristics of these drugs, and also find out whether they differ from each other.

Creon cheap analogues

Today it is difficult to meet a person who does not take enzyme preparations, and it is almost impossible to find someone who has not heard anything about them. What kind of medications are we taking for diseases of the pancreas (pancreatitis), for functional problems of the biliary tract, for poisoning and various lesions of the gastrointestinal tract? Why is it difficult to imagine any stormy feast without various analogues of enzyme preparations? What is better to take for pancreatitis - Mezim Forte, Pangrol, Festal, Ermital or Creon? This is exactly what we will talk about in our article.

Pancreatic enzymes - drugs, which one is better?

Every day I hear a huge number of questions from my patients. They all want to hear the doctor’s feedback on what is better: Festal or Creon? Or maybe Mezim Forte? What is better to take for pancreatitis, cheap Pancreatin or expensive Creon?

In order to understand the whole essence of the issue, let's first understand what digestive enzymes and pancreatic enzyme preparations are, what they are needed for, and then I will answer questions and write reviews about which drug is better.

Mezim Forte or Creon - which is better?

One of the most common and well-known enzyme preparations is Creon, produced by the American company Abbot. It is presented on the market in two forms of release: Creon 10000 and Creon 250000.

Mezim Forte is also a fairly well-known enzyme preparation produced by the German company Berlin-Chemie; it can be found in pharmacies in two dosages:

Mezim Forte 10000 and Mezim Forte 20000.

For clarity and convenience in comparing the composition, I presented these drugs in a table.

As can be seen from the tablet, the composition of Creon and Mezim Forte is the same, and the dosages are almost identical. Creon contains a little more enzymes.

When the minimicrospheres reach the small intestine, the enteric coating is rapidly destroyed (at pH 5.5), releasing enzymes with lipolytic, amylolytic and proteolytic activity, resulting in the breakdown of fats, carbohydrates and proteins. This drug has a large evidence base and, accordingly, the highest price on the market among similar drugs. He's really good. All other drugs, including Mezim Forte, Pangrol, Festal, Mikrasim, Pancreatin, Ermital, are generic drugs. During production, all of them took the Kroen molecule as a basis, and ultimately sought to be as similar in therapeutic and pharmacological properties to the original drug as possible.

Therefore, answering the question of whether it is better to mix forte or creon, I will make a slight advantage in favor of Creon:

• Original drug;
• More innovative technologies: enzymes are in the form of minimicrospheres coated with an enteric (acid-resistant) coating, which increases the therapeutic activity of the drug;
• The only negative is the high price.

Next, I want to give a list of good analogues of Creon, which are cheaper:

Which is better - Creon or Pancreatin for pancreatitis?

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Skalitsky Alexander Igorevich

Education: 1984 – graduated from the Kharkov State Medical Institute, General Medicine. 1992 –.

Skalitskaya Alena Alexandrovna

Education: graduated from Kharkov National Medical University, general medicine. G. -.

Skalitsky Mikhail Alexandrovich

Education: graduated from Kharkov National Medical University, general medicine. .

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Analogs

It should not be combined with other digestive enzymes, as this increases the risk of adverse reactions.

In addition, they reduce the absorption of iron, which is why it is not recommended to take enzymes along with vitamins.

If the drugs are not suitable for some reason, you can replace them with the following drugs:

• Mezim and Festal in tablet form;
• Digestin syrup;
• Unienzyme.

Any pharmacy will stock a dozen products based on pancreatin: in tablets or capsules, with or without pellets and microgranules. More than 20 of their variations can be compared in a convenient table. In this review, we will look at two, at first glance, similar representatives - Micrasim and Ermital, the difference between which in fact is significant.

Creon cheap analogues

Today it is difficult to meet a person who does not take enzyme preparations, and it is almost impossible to find someone who has not heard anything about them. What kind of medications are we taking for diseases of the pancreas (pancreatitis), for functional problems of the biliary tract, for poisoning and various lesions of the gastrointestinal tract? Why is it difficult to imagine any stormy feast without various analogues of enzyme preparations? What is better to take for pancreatitis - Mezim Forte, Pangrol, Festal, Ermital or Creon? This is exactly what we will talk about in our article.

Pancreatic enzymes - drugs, which one is better?

Every day I hear a huge number of questions from my patients. They all want to hear the doctor’s feedback on what is better: Festal or Creon? Or maybe Mezim Forte? What is better to take for pancreatitis, cheap Pancreatin or expensive Creon?

In order to understand the whole essence of the issue, let's first understand what digestive enzymes and pancreatic enzyme preparations are, what they are needed for, and then I will answer questions and write reviews about which drug is better.

Mezim Forte or Creon - which is better?

One of the most common and well-known enzyme preparations is Creon, produced by the American company Abbot. It is presented on the market in two forms of release: Creon 10000 and Creon 250000.

Mezim Forte is also a fairly well-known enzyme preparation produced by the German company Berlin-Chemie; it can be found in pharmacies in two dosages:

Mezim Forte 10000 and Mezim Forte 20000.

For clarity and convenience in comparing the composition, I presented these drugs in a table.

As can be seen from the tablet, the composition of Creon and Mezim Forte is the same, and the dosages are almost identical. Creon contains a little more enzymes.

When the minimicrospheres reach the small intestine, the enteric coating is rapidly destroyed (at pH 5.5), releasing enzymes with lipolytic, amylolytic and proteolytic activity, resulting in the breakdown of fats, carbohydrates and proteins. This drug has a large evidence base and, accordingly, the highest price on the market among similar drugs. He's really good. All other drugs, including Mezim Forte, Pangrol, Festal, Mikrasim, Pancreatin, Ermital, are generic drugs. During production, all of them took the Kroen molecule as a basis, and ultimately sought to be as similar in therapeutic and pharmacological properties to the original drug as possible.

Therefore, answering the question of whether it is better to mix forte or creon, I will make a slight advantage in favor of Creon:

• Original drug;
• More innovative technologies: enzymes are in the form of minimicrospheres coated with an enteric (acid-resistant) coating, which increases the therapeutic activity of the drug;
• The only negative is the high price.

Next, I want to give a list of good analogues of Creon, which are cheaper:

Which is better - Creon or Pancreatin for pancreatitis?

Enter the site

We are in social networks

Our doctors

Skalitsky Alexander Igorevich

Education: 1984 – graduated from the Kharkov State Medical Institute, General Medicine. 1992 –.

Skalitskaya Alena Alexandrovna

Education: graduated from Kharkov National Medical University, general medicine. G. -.

Skalitsky Mikhail Alexandrovich

Education: graduated from Kharkov National Medical University, general medicine. .

Ask your doctor any question you have for free!

+ Ask a question

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Which is better - Festal or Mezim? Selecting Mezim analogues correctly

The modern rhythm of life forces a person to do everything “on the run” #8212; meet, solve business issues and return to work again. Returning home, take a shower and fall on the bed so that in the morning you will fall into the same wheel again.

There is sorely not enough time for a nutritious meal, so eating is also “on the run” #8212; sandwiches, fast food, snacks and only in the evening - “for the whole day.”

This rhythm leads to disruptions in the functioning of the digestive tract. In many cases, drugs containing enzymes come to the rescue. They help regulate food digestion processes. Mezim and Festal are perhaps the most famous and in demand.

In the morning you will come out with a lump of worms if you drink a spoonful of simple Soviet. »

What if they are not available in the pharmacy or there are certain contraindications? There is a way out - analogues and substitutes also effectively help solve the problem.

Everyone must remember that there must be clear indications for taking enzyme preparations. Otherwise, you can bring the pancreas (it is its enzymes that are part of the products under consideration) to complete atrophy.

Mezim or Pancreatin

Pancreatin is an enzymatic complex that is extracted from the pancreas of animals (cattle, pigs and poultry). It includes:

• Amylase, which breaks down carbohydrates;
• protease processes proteins;
• lipase - carbohydrates.

There is also a drug of the same name. But it is pancreatin that is included in all products that promote digestion and supply the body with missing enzymes. You should choose Pancreatin or Mezim based on the amount of active ingredients.

There are many drugs that contain Pancreatin:

• Festal;
• Panzinorm;
• Penzital;
• Motilium;
• Micrasim;
• Creon;
• Pangrol;
• Enzistal;
• Pankrenorm;
• Panzim;
• Ermital and many others.

But the most popular analogue of Pancreatin was and remains Mezim. Although the other drugs are in no way inferior to this “sweet couple”.

What are the differences between the drugs

The main difference is the concentration of the amylase enzyme. This is usually the number in the name of the medicine. Mezim Forte 10000 contains the same amount of amylase. Analogues of Mezim Forte in concentration are Creon, Panzinorm and Mikrazim with the corresponding number in the name.

Therefore, you can choose not only Mezim or Pancreatin, but also analogues, depending on the general condition, the cause of digestive disorders and the degree of damage to the pancreas.

Indications and features of use

Before taking any enzyme preparation, you need to know about the cases when it is indicated for use.

This therapy is usually prescribed for the following ailments and conditions:

Only in the last two cases can you take Mezim or Pancreatin or their analogues on your own. In all others, consultation with a specialist is required to select an effective dosage. This is done on the basis of diagnostic measures to determine the condition of the pancreas.

If a person only needs temporary support, the dosage will be small. If the gland does not work at all, then therapy will most likely be constant and in fairly high doses.

You should know that if you have diarrhea caused by even banal overeating, you cannot take bile-containing medications. Consequently, the answer to the question - Festal or Mezim, will be decided in favor of Mezim.

Mezim's analogs

As we have already found out, Mezim analogues are very diverse both in the amount of pancreatic enzymes and in the form of release and additional components. Let's look at the most common, well-known and affordable ones.

Pancreatin

Festal has a number of contraindications that are not listed in the instructions for use of Mezim. According to reviews, this remedy also causes side effects in the form of diarrhea, sour belching, and in some cases, heartburn.

This once again proves that the use of any medicine must be agreed with a specialist in order to avoid troubles during treatment.

Creon is an expensive analogue of Mezim. It is available in the form of gelatin capsules, the shell of which dissolves only in the small intestine. Enzyme concentrations may be similar. But it is Creon Mezim that is superior to the drug with the maximum amount of amylase. That is, if large doses are needed, preference is still given to Creon.

The drug is prescribed to restore the functioning of the digestive system, impaired due to the use of other medications, as well as for diseases characterized by increased flatulence.

Pangrol is a very high-quality analogue of Mezim Forte, but at a slightly higher price. It effectively restores the functioning of the gastrointestinal tract in various pathologies; it is indicated for diarrhea caused by insufficiency of the secretory functions of the pancreas. In case of exacerbation of chronic pancreatitis or during an acute attack of the primary disease, it is not recommended to take it.

Other analogues and substitutes

Now let’s dwell a little on lesser-known, but no less effective drugs, which can be called a Mezim substitute. Let's start with the most highly concentrated one.

Mezim can be replaced with a drug such as Motilium. It does not contain Pancreatin, but even has some advantages over enzymatic preparations, since it is able to stop attacks of vomiting, cope with gas formation and bloating, improves gastric and intestinal motility, and promotes high-quality excretion of feces during stagnant processes.

Share information on social networks, like and be healthy without drugs. But it is useful to know about them, since health is a very fragile thing.

The pancreas produces its own enzymes that help digest food and monitor the breakdown of proteins, fats, and carbohydrates, helping them to be absorbed by the body. If the pancreas does not cope with its function, the digestive process is disrupted, which can lead to undesirable consequences and serious illnesses.

To help the gland, pharmaceuticals have developed enzyme preparations that help restore the functioning of the gastrointestinal tract. Such helpers include Hermital and Creon. Which medicine helps faster? Let's figure it out by examining both means.

Which is better: Creon or Micrasim

When purchasing an enzyme preparation for treatment or temporary use in cases of overeating or diet violations, you often have to choose between the drugs Creon and Micrasim. It is quite difficult to determine which is better, because the drugs are very similar to each other. This can be clearly seen when comparing their advantages and disadvantages.

Advantages and disadvantages of Creon

Creon is a branded product. It was he who was the first patented enzyme preparation.

• produced by a world-famous pharmaceutical company that conducts numerous tests and improvements of the drug;
• the presence of a release form of Creon 40000, which makes it easier to take the medicine if it is necessary to use high doses of pancreatin;
• no age restrictions for admission;
• ease of dose selection for small children (you can open the capsule, select the required number of minimicrospheres and mix them with food);
• proven effectiveness in chronic pancreatitis, gastrectomy, cystic fibrosis, pancreatectomy, Shwachman-Diamond syndrome, in the postoperative period after surgery on the gastrointestinal tract;
• the possibility of prescribing for other pathologies and conditions requiring the use of enzymes, at the discretion of the doctor;
• the tiny size of minimicrospheres ensures uniform mixing with the stomach contents, which increases efficiency;
• the acid-resistant shell ensures delivery of the active substance without loss to the place of its action - the intestines.

• high price;
• presence of contraindications (hypersensitivity, acute pancreatitis);
• the possibility of developing side effects (gastrointestinal disorders, allergic reactions);
• in case of overdose causes hyperuricemia and hyperuricosuria;
• with long-term use, it can provoke the development of fibrous colonopathy;
• a ban on chewing the contents of the capsules (some people, often children, cannot swallow the drug without first chewing it);
• the need to mix the granules before taking only with food or drinks with an acidic environment (if it is impossible to swallow the capsule whole or if you are taking a smaller dose of the medicine).

Advantages and disadvantages of Micrasim

• High-quality German substance Nordmark AG is used for production;
• the cost of the drug is more affordable, this is especially noticeable with prolonged use;
• can be used by patients of any age: from birth to old age;
• a wide range of indications: chronic pancreatitis, cystic fibrosis, pancreatic cancer, pancreatectomy, conditions after surgical interventions on the digestive organs, diseases accompanied by deterioration of bile secretion, disorders of chewing function, overeating;
• the ability to separate the contents of capsules to select the exact dose;
• the presence of an acid-resistant shell of microgranules, which protects pancreatin from destruction in the stomach;
• the presence of simethicone in the composition of excipients, which eliminates bloating;
• small granule sizes, ensuring uniform mixing with chyme and unhindered penetration into the intestines.

• little-known manufacturer;
• presence of contraindications (hypersensitivity and acute pancreatitis);
• the likelihood of developing “side effects” (nausea, diarrhea, epigastric pain, allergies);
• in case of overdose, it causes an increase in uric acid levels in the blood and urine, as well as constipation in children;
• long-term use can cause the formation of strictures in the intestine;
• Do not chew the granules;
• The granules can only be mixed with food and drinks with an acidic environment.

What is the pancreas responsible for?

The pancreas performs several functions:

• digestive – responsible for the process of breaking down food consumed, proper absorption and distribution of nutrients from it throughout the body;
• humoral - regulates the level of gland juice and helps distribute animal fluids within the body;
• secretory - determined by the amount of pancreatic juice and enzymes inside it;
• endocrine - helps synthesize hormones and enzymes necessary for normal life.

When food enters the stomach, the pancreas changes the composition of the secreted juice and the ratio of enzymes contained in it. If the juice is not produced in the right quantity, the food will not be able to be broken down. Hydrochloric acid will begin to destroy the mucous membranes of the stomach and intestines. Metabolic disorders will occur with the appearance of serious diseases, accompanied by pain and loss of strength.

Importance of the pancreas

Pancreas changes the composition of pancreatic juice, changing the ratio of its main enzymes. This process starts the moment food enters the body.

If the natural production of substances stops or a failure occurs in the process, then the normal breakdown of food will become impossible. Under the influence of acids, the process of destruction of the walls of the stomach and intestines will begin.

The main functions of the pancreas are:

1. Humoral, which regulates the distribution of animal fluids throughout the human body, is responsible for the level of pancreatic juice. This function promotes the production of the required amount of enzymes for good digestibility of food.
2. Digestive, which responds to the proper breakdown of food entering the body. The juice, which is produced and participates in the digestion process, allows beneficial substances to penetrate the bloodstream and spread throughout the body.
3. Endocrine, which is responsible for the synthesis of vital enzymes and hormones in the body. For example, insulin levels, deviations from which lead to the development of diseases.
4. Secretory, which is primarily determined by pancreatic juice and the enzymes and organic substances it contains.

If the pancreas does not function properly, the body's metabolism malfunctions and serious diseases develop, which are accompanied by pain and a general loss of strength.

If the pancreas stops performing its basic functions, this risks the development of dangerous diseases, including diabetes and pancreatitis. Treatment of inflammation and malfunction of the gland requires the vigilant attention of a doctor and the use of a course of medications; surgical intervention is resorted to in the most advanced cases.

Release form

Creon normalizes the digestive process and helps nutrients be absorbed into the body. It is prescribed to children with cystic fibrosis.

The product is sold in pharmacies without a doctor's prescription, in blisters with transparent capsules of 10 and 25 pieces in one blister, as well as in polypropylene bottles with different contents of the active ingredient (20, 50 and 100 pieces each). There are three types of Creon: 10,000, 25,000, 40,000. The numbers determine the quantitative content of the main enzyme substance.

Ermital helps restore the deficiency of pancreatic enzymes.

The active substance is contained in capsules in quantities of 10,000, 25,000, 36,000 units. Available without a prescription.

What are active enzymes responsible for?

• Pancreatin contains three main enzymes: amylase, lipase and protease. The first enzyme is responsible for the breakdown of carbohydrates into monosaccharides and their derivatives.
• Lipase is responsible for the process of fat breakdown. It is its quantity that is determined in the designation of the drugs: the higher the number, the stronger and more effective the medicine.
• Protease works with proteins found in food pieces, breaking them down into amino acids and peptides.

If the level of your own enzymes is reduced, the active substances of medications help compensate for their deficiency and normalize the digestion process.

The pharmacology of the active substance is such that they help the body cope with the problem, bypassing the bloodstream.

The role of pancreatic enzymes

It is difficult to identify the most important elements that make up the pancreatic juice; each is responsible for its own area and performs a function necessary for life.

There are three main enzymes:

The listed substances can be found in the mouth, stomach and small intestine; each of them is responsible for the breakdown of certain substances, and together they help maintain the process of digestion and absorption of food in a balanced state.

For example, lipase is responsible for the breakdown of fats, amylase takes on the work with carbohydrates, and protease takes on the work with proteins. In medical practice, there are established standards that determine the balance of substances in the adult body.

If the level of enzymes decreases, which has a detrimental effect on health, then doctors recommend resorting to therapy with special drugs. In the modern pharmacological market, the drugs “Ermital” and “Creon” have become very popular. They are largely similar in composition; the main active ingredient is pancreatin, extracted from the pig pancreas. The composition of these drugs includes lipase, amylase and protease, which compensate for the lack of enzymes.

The attending physician determines which drug to choose for drug therapy.

Indications for use of drugs

Both remedies help with:

• liver cirrhosis;
• cystic fibrosis, when the gland secretes an insufficient amount of enzymes;
• chronic form of pancreatitis;
• problems with the biliary tract and their obstruction;
• pancreatic cancer;
• indigestion due to partial resection of the stomach;
• chronic inflammation of the stomach and gastrointestinal tract;
• dysbacteriosis and disorders of diet, chewing function associated with a sedentary lifestyle and place of work.

Main characteristics of Hermital

The drug "Ermital" is used in cases where it is necessary to replenish the missing pancreatic enzymes in the human body. Available in the form of capsules with different pancreatin contents, which shows the level of activity of the active substance.

The following types of Hermital are distinguished:

1. Ermital 10,000 units.
2. Ermital 25,000 units.
3. Ermital 36,000 units.

The variety of enzymatic activity of the drug allows you to make the most optimal choice when developing the main therapy.

When using drugs containing enzymes, it is important that the main active ingredients reach the desired area of ​​the human body. For this reason, the capsule shell is designed in such a way that it is not destroyed by gastric juice; the main action occurs in the intestines.

The active substances are absorbed into the intestinal walls, providing the necessary pharmacological effects without entering the bloodstream.

Indications for use of the drug:

1. Prevention of the digestive process, elimination of the consequences of poor nutrition.
2. Inflammation and insufficiency of the pancreas.
3. Pancreas cancer.
4. Cystic fibrosis.
5. Chronic pancreatitis.
6. Digestive failure due to gastric resection.
7. Dysbacteriosis.
8. Cirrhosis of the liver.
9. Obstruction of the biliary tract.

The advisability of using the medicine and its dosage is determined only by the attending physician. Self-medication can be dangerous to health; incorrect dosage of enzymes will worsen the condition of the gastrointestinal tract.

Contraindications include individual intolerance or hypersensitivity to the components of the drug; no other factors limiting its use have been identified.

Apricot and corn for hepatitis C

As mentioned above, the doctor must select the correct dosage in order to restore the balance of pancreatic enzymes as effectively as possible. Most often, the amount of the drug is determined by the patient’s age, weight, and the main indication for use.

Ermital capsules are swallowed whole during a meal, washed down with plenty of water. Violation of the integrity of the shell, its fragmentation, will lead to the loss of the main effect of the drug, since its more active substances will lose protection from gastric juice. During therapy with Hermital, it is recommended to drink large amounts of fluid.

In medical practice, possible side effects from the use of an enzyme preparation have been identified. Most of them are associated with the underlying human disease. Abdominal pain, diarrhea, nausea, vomiting and bloating may occur. In rare cases, the patient develops a rash and itchy skin.

With all these comments, Ermital has proven its effectiveness and, with a competent course of treatment, will not cause harm to health or cause discomfort.

How to use Ermital and Creon

According to the instructions for use of both drugs, there is a general rule for taking medications containing active enzymes.

1. The capsule must be swallowed without violating the integrity of the shell and without dissolving it.
2. Next, you need to drink plenty of plain water (at least half a glass). The active enzyme must enter the small intestine to begin its action there. Otherwise, you can damage the mucous membranes of the mouth and esophagus.

It is necessary to drink water throughout the entire course of taking the medicine. Plenty of fluid helps metabolism and normalizes stool.

Medicines should be taken during or immediately after meals, one to two capsules at a time. The dosage and duration of the course are determined by the doctor depending on the presence of the disease, its symptoms and severity.

special instructions

Before taking it, it is important to carefully read the instructions for use to avoid negative consequences.

During this period, you can take it only if the benefits of the products outweigh the harm to the body of the mother and child. It is not advisable to self-medicate during such a period. It is important to consult a doctor.

Childhood

Children under 6 years of age should not take the drug; for older children, the dosage depends on the weight and condition of the patient.

Elderly age

Patients over 60 years of age can take Mikrasim and Pancreatin, but only after consulting a gastroenterologist.

Similarities of drugs

1. Creon and Ermital are analogues of German origin. This allows doctors to correctly use the drugs in practice to treat diseases of the gastrointestinal tract.
2. The medications have the same active ingredient - animal pancreatin, isolated from the pancreatic juice of the pig pancreas.
3. Both products are available in enteric capsules, in three types, depending on the lipase content. Ermital 36,000 is more powerful in its action than Creon 40,000. The two other types of both drugs contain 10 and 25 thousand units of lipase, respectively.
4. The rules for taking medications are the same. If the integrity of the capsule is violated before it enters the small intestine, the effect of the active substance may decrease and harm the mucous membranes that are not involved in the process of digestion and breakdown of food. The resulting ulcers will take a long and painful time to heal.
5. The contraindications of the drugs are identical and have the same side effects on the human body.
6. Both drugs can be prescribed to children to restore digestion after bouts of severe diarrhea. Treatment of pancreatic insufficiency in cystic fibrosis in children is also carried out by any of the means.

Main characteristics of Creon

The drug "Creon" is also available in the form of capsules, with different dosages of the active substance pancreatin. The Ermital and Creon being considered are analogues of each other, which allows you to individually select a treatment option.

There are the following types of Creon:

1. Creon 10,000 units;
2. Creon 25,000 units;
3. Creon 40,000 units.

The main active ingredient is identical to the drug "Ermital", the main difference is in the set of auxiliary components.

If you believe the reviews about Creon, the drug shows equally good results in the treatment of adults and children. It is considered the most common means of enzyme therapy in Europe.

Indications for use:

1. Development of pancreatitis in chronic form.
2. Cystic fibrosis.
3. Pancreatic oncology.
4. Ductal obstruction.
5. Decrease in basic pancreatic function in old age.
6. Cirrhosis of the liver.
7. Recovery after partial gastrectomy.
8. Obstruction of the biliary tract.
9. Development of pathologies of the small intestine, including the growth of bacteria in the small intestine.

Given that the drug is well tolerated in childhood, it is often prescribed for recovery from bouts of diarrhea.

The list of contraindications for Creon is small.

In addition to individual hypersensitivity to the components of the drug, the following restrictions are identified:

• It is not recommended to use Creon in the acute stage of pancreatitis;
• do not use the drug in the early stages of pancreatitis.

To avoid undesirable consequences from a possible overdose of enzymes, it is important to vigilantly monitor symptoms in the abdominal area and regularly monitor your health with your doctor.

Creon capsules are also taken during meals, washed down with plenty of water. It is not recommended to violate the integrity of the capsule shell. The required dosage is determined only by a specialist who, when prescribing, takes into account all the individual health characteristics of the patient, as well as his age, weight and underlying disease.

Treatment with Creon should be accompanied by drinking plenty of fluids, which will help reduce the risk of constipation.

How does Creon differ from Hermital?

1. Ermital is a cheap analogue of Creon. The price ratio for the products is approximately 1: 2. Therefore, 50 capsules of Ermital 25,000 units will have the same cost as 20 capsules of Creon with the same amount of lipase.
2. Creon contains a variety of excipients.
3. In enzyme replacement therapy, Creon is used more often than other drugs. It helps cure childhood cystic fibrosis and normalizes the amount of enzymes in older people.
4. When taken simultaneously with folic acid, Ermital reduces the level of absorption of the latter.
5. Creon is not recommended to be taken with iron-containing medications, so that the enzyme does not interfere with the proper absorption of iron. Antacid substances, on the contrary, reduce the effect of taking the fermented product.
6. For proper use, it is necessary to wait 30-40 minutes between taking incompatible drugs.

Comparison of side effects of Creon 1000i and Ermitali

Side effects or adverse events are any adverse medical event that occurs in a subject after administration of a drug.

Creon 1000 and the state of undesirable effects are almost the same as Ermital. They both have few side effects. This implies that the frequency of their occurrence is low, that is, the indicator of how many cases of an undesirable effect of treatment are possible and registered is low. The undesirable effect on the body, the strength of influence and the toxic effect of Creon 1000 is similar to Hermital: how quickly the body recovers after taking it and whether it recovers at all.

Adverse reactions of the body and contraindications to taking medications

If a person has an allergic reaction to pork, do not take any of the medications. The same applies to individual intolerance and hypersensitivity to one of the main or auxiliary components of Hermital and Creon.

• During the period of exacerbation of chronic pancreatitis and acute pancreatitis, medications should not be taken.
• Adverse reactions to drug overdose are the same. In case of severe overdose, the level of uric acid in the urine and blood may be elevated, as a result of which fibrous colonopathy may develop.
• Allergies can manifest themselves in the form of urticaria and skin dermatitis, and in rare cases, anaphylactic shock.

Possible reactions from the gastrointestinal tract: nausea, diarrhea, constipation and abdominal pain. When comparing experimental results, complaints about organ failure were more likely to occur during a therapeutic transition to Ermital. However, it should be noted that similar symptoms may be caused by an underlying disease.